Partition Coefficient

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Partition Coefficient In the pharmaceutical industry, the partition coefficient refers to the concentration ratio of a compound in two phases of two incompatible liquid mixtures in equilibrium. In the process of drug absorption, the partition coefficient indicates how and to what extent the drug dissociates and then passes through the cell barrier and finally is absorbed. Its key role is to ensure and maintain an appropriate proportion of drug absorption in a selective biological environment. The determination of partition coefficient in preformulation studies can provide useful information for the development of a stable and suitable dosage form for pharmaceutical in the future. For example, in the design of the experimental scheme for separation and purification of active pharmaceutical ingredients, the predicted partition coefficient can help to select the most appropriate solvent system and the best process conditions.

Alfa Chemistry has a professional analysis team and advanced instrumentation to meet the pharmaceutical industry's various testing needs, no matter at what stage your pharmaceutical research is, Alfa Chemistry can provide you with the most comprehensive testing services. Our experts can customize personalized testing services according to your requirements when you are confused. In addition to the determination of partition coefficient we can also provide a range of pharmaceutical physical and chemical properties testing services. Please feel free to contact us if you need any testing services in your pharmaceutical research.

Alfa Chemistry's physical characterization services of pharmaceutical include:

Alfa Chemistry's technology platforms include but not limited to:

Ultraviolet-Visible (UV/Vis) Spectroscopy
Enzyme Linked Immunosorbent Assay (ELISA)
Two-dimensional Difference Gel Electrophoresis (2-D DIGE)
Hydrophobic Interaction Chromatography (HIC)
Reversed Phase High-performance Liquid Chromatography (RP-HPLC)
Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry (FTICR-MS)
MALDI-TOF-MS
ESI-QTOF-MS
LC-MS/MS

Some resources for measuring partition coefficient:

OECD 107 - Partition Coefficient (n-octanol/water): Shake Flask Method
OECD 117 - Partition Coefficient (n-octanol/water): HPLC Method
OECD 123 - Partition Coefficient (1-Octanol/Water): Slow-Stirring Method

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