Agilent 1290 Infinity III Bio LC System

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Note: this service is for Research Use Only and Not intended for clinical use.

The Agilent 1290 Infinity III Bio LC System is a high-performance UHPLC platform specifically engineered for the analysis of sensitive biomolecules, including monoclonal antibodies (mAbs), proteins, peptides, and oligonucleotides. Featuring a fully bioinert flow path and ultralow-dispersion design, the system preserves biomolecule integrity while delivering exceptional chromatographic resolution and reproducibility.

Designed for demanding biopharmaceutical workflows, the platform supports a wide range of bioseparation techniques, including size exclusion chromatography (SEC), ion exchange chromatography (IEX), reversed-phase chromatography (RP), and hydrophobic interaction chromatography (HIC).

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Key FeaturesTechnical SpecificationsApplications

Bioinert flow path constructed with PEEK, ceramic, and corrosion-resistant materials to minimize analyte interaction and maintain biomolecule integrity
Ultra-high pressure operation up to 1300 bar for high-resolution UHPLC separations
Ultralow dispersion and delay volume for maximum chromatographic efficiency
High salt tolerance up to 2 M and pH compatibility from 1–13 (up to 14 for short-term exposure)
Binary or quaternary gradient configurations with Jet Weaver mixing technology
Compatible with UV, DAD, FLD, Bio MDS, and LC/MS detection systems
InfinityLab Assist for remote monitoring, diagnostics, and workflow automation
ACT Environmental Impact Label supporting laboratory sustainability initiatives

Parameter	Specification
Maximum Pressure	Up to 1300 bar
Flow Rate Range	Up to 5 mL/min
Injection Volume	0.001–500 μL
Expanded Injection Volume	Up to 1500 μL
Gradient Formation	Binary or Quaternary
Column Capacity	Up to 8 Columns
pH Range	1–13 (Short-Term 14)
Salt Tolerance	Up to 2 M
Bioinert Construction	Yes
Detection Options	VWD, DAD, FLD, Bio MDS, LC/MS

The Agilent 1290 Infinity III Bio LC System is ideal for advanced bioanalytical and biopharmaceutical applications, including:

Monoclonal antibody (mAb) characterization
Protein and peptide analysis
Oligonucleotide analysis
Biopharmaceutical research and development
Biosimilar and biologic quality control
Bioseparation method development

The Agilent 1290 Infinity III Bio LC System significantly enhances biomolecular analysis capabilities by providing a dedicated bioinert UHPLC platform for high-resolution bioseparations. Its combination of biomolecule-friendly materials, ultrahigh-pressure performance, and advanced automation ensures reliable characterization of complex biological samples while maintaining analytical accuracy and throughput. This system strengthens ability to support biopharmaceutical development, quality control, and advanced bioanalytical testing projects.

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