TA Instruments Nano DSC

• Measures subtle heat changes associated with protein unfolding and other biomolecular transitions with excellent sensitivity and reproducibility.
• Evaluates proteins, nucleic acids, lipids, and other biomolecules without fluorescent dyes or external reagents, preserving native sample conditions.
• Determines melting temperature (Tm), unfolding enthalpy, and heat capacity changes from a single experiment for in-depth stability assessment.
• Optional autosampler supports temperature-controlled 96-well plates, automated sample loading, cleaning, and unattended operation for improved laboratory efficiency.
• Software-controlled operation allows precise programming of temperature ranges and scan rates to accommodate diverse research applications.

The TA Instruments Nano DSC is widely used for the thermal characterization of proteins, monoclonal antibodies, enzymes, vaccines, nucleic acids, lipids, and other biomolecules, supporting formulation development, comparability studies, protein engineering, biosimilar characterization, quality assessment, and stability evaluation throughout biopharmaceutical research, manufacturing, and storage. The instrument is also valuable for investigating protein folding, ligand interactions, and the effects of environmental conditions on biomolecular structure and stability.