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Vehicle Selection
Online InquiryThrough our global network of testing experts and analytical equipment including chromatography (HPLC, GC, GC/MS) and atomic absorption spectroscopy (AAS, GFA, FIAS), Our goal is to provide test services as efficiently as possible to maximize our customers' profits. For more information about our services, contact one of our experts today.
Note: this service is for Research Use Only and Not intended for clinical use.
Drug vehicle is a carrier or inert medium used as a solvent (or diluent) in which a medicinally active agent is formulated and or administered. [1] Drug vehicles can change the form of drug, control the speed of drug release and make the drug reach the target organ more accurately. At the same time, with the assistance of drug vehicle, the degradation and loss of drug can be reduced, and the side effects can be reduced. However, in the selection of the vehicle, consideration should be given to the complexity of the preparation, homogeneity of the mixture, and handling procedures as these can result in decreased accuracy in dose delivery. [2]
As a global leading pharmaceutical analysis services company, Alfa Chemistry has established a unique high-throughput screening (HTS) method, which can automate the screening process and provide our clients with a highly efficient vehicle selection service. In addition, other preformulation analysis services are also available. Alfa Chemistry is the perfect partner for getting expertise, flexibility, and reliability with your pharmaceutical formulation project.
Alfa Chemistry offers the following services for vehicle selection:
Sample Handling
Sample handling processes, depending on the stability of the drug substance in the screening media, or the ability of a drug product coating to prevent exposure to a drug substance that is unstable in the screening media.
Integrity, Potency, Stability, and Homogeneity
Integrity: A qualified vehicle should be shown to maintain the drug substance quality attributes. If the drug product has a coating and is used intact, the qualified vehicle should have no impact on the coating and as a result, on the integrity of the drug substance within the drug product. In the cases where a coated tablet is to be crushed before mixing and the integrity of the coated tablet is intentionally compromised, or where the drug product dissolves in the vehicle, exposing the drug substance, the potential for the proposed vehicle to impact the integrity of the drug substance (e.g., changes in polymorphic form, loss of bead integrity) should be evaluated.
Potency (assay): Potency assessment should determine the amount of the drug substance in the drug product-vehicle mixture to support the recommended labeled use time.
Stability: Stability assessment of the drug product-vehicle mixture should be provided to support labeling instructions for its preparation and labeled use time.
Homogeneity: The proposed vehicle(s) should also be suitable for preparation of homogeneous mixtures. The more homogeneous the drug and vehicles are, the more reliable the estimate of the ingested dose.
Dissolution/Drug Release Testing
Ingredients can alter release and delivery of drug substance from the drug product.
Dosage Form Specific Considerations
For liquid drug products such as syrups, emulsions, or similar dosage forms, it may be possible to mix the drug product homogenously with the vehicle.
Our advantages:
Short Detection Cycle
Competitive Price
Years of Experience
Professional Equipment
Reliable Results
Compliance with Various Standards
References
Dictionary of Pharmacy, 1986.
Use of Liquids and/or Soft Foods as Vehicles for Drug Administration: General Considerations for Selection and In Vitro Methods for Product Quality Assessments Guidance for Industry. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). July 2018 Pharmaceutical Quality/CMC.
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Do not know how to place an order, please refer to the flow chart shown below.
Submit quotation request |
A technical manager will contact you within 24 hours |
You will review and approve the final price and place an order |
Confirm with you and make the payment |
Instruct you to ship your samples and form |
Analytic report delivery |
