Hygroscopicity Assessment

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Note: this service is for Research Use Only and Not intended for clinical use.

Hygroscopicity is the ability of a material to absorb or adsorb moisture from surrounding environment.^[1] It is well-known that the water content of solid drug substance and excipients, individually and when formulated in pharmaceutical dosage forms, is an important parameter that should be monitored throughout the process of drug product development. Hygroscopicity of pharmaceutical solids is often evaluated due to uptake of unacceptable amount of water can cause adverse effects on physical and chemical stability of APIs and functionality of excipients.^[2] In recent years, hygroscopicity has become one of the most important criteria in selecting solid form of a drug substance for development. In pharmaceutical industry, the most commonly used conventional method for hygroscopicity is as per the European Pharmacopeia (Ph. Eur.).

Hygroscopicity Assessment Olmesartan Medoxomil ^[1]

As a global leading pharmaceutical analysis services company, Alfa Chemistry provides hygroscopicity and other preformulation analysis services according to related standards for minimizing the potential formulation and stability problems. Alfa Chemistry is the perfect partner for getting expertise, flexibility, and reliability with your pharmaceutical formulation projects.

Alfa Chemistry's reference methods for pharmaceutical hygroscopicity assessment:

Gravimetric Sorption Analysis (GSA) Method
The Ph. Eur. Method

Our advantages:

Short Detection Cycle
Competitive Price
Years of Experience

Professional Equipment
Reliable Results

References

Allada, R. (2016). Hygroscopicity Categorization of Pharmaceutical Solids by Gravimetric Sorption Analysis: A Systematic Approach. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm, 10(04).
Chen, D. (2009). Hygroscopicity of pharmaceutical crystals.

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