Waters Xevo G3 QTof

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Note: this service is for Research Use Only and Not intended for clinical use.

The Waters Xevo G3 QTof is a high-performance quadrupole time-of-flight (QToF) mass spectrometer designed to deliver accurate, sensitive, and rapid analytical results across a wide range of applications. Combining advanced ion optics, high-resolution mass analysis, and robust quantitative capabilities, the system provides reliable characterization of compounds ranging from small molecules and metabolites to peptides, proteins, and other complex biomolecules.

Engineered for both qualitative and quantitative workflows, the Xevo G3 QTof offers exceptional sensitivity, mass accuracy, dynamic range, and acquisition speed. Its ability to generate high-quality data from complex matrices and trace-level samples makes it a valuable analytical platform for many fields.

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Key FeaturesTechnical SpecificationsApplications

The Xevo G3 QTof incorporates advanced StepWave™ XS ion optics, which maximize ion transmission efficiency while minimizing signal losses.
The system delivers high-resolution accurate-mass measurements with up to 1 ppm RMS mass accuracy in both MS and MS/MS modes.
The combination of QuanTof™ detection technology and the optimized XS collision cell provides excellent sensitivity, selectivity, and dynamic range.
The instrument supports multiple atmospheric pressure ionization techniques, including electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), broadening its versatility across sample types.
Integrated with industry-leading software platforms such as MassLynx™ and UNIFI™, the Xevo G3 QTof simplifies method development, data acquisition, processing, and reporting, helping laboratories improve efficiency and accelerate decision-making.

Parameter	Specification
TOF Mass Range	m/z 20–100,000
Quadrupole Mass Range (Non-Resolving Mode)	m/z 20–16,000
Quadrupole Mass Range (Resolving Mode)	m/z 20–4,000
Mass Accuracy	1 ppm RMS (MS and MS/MS)
Resolution Mode	> 40,000 FWHM
Sensitivity Mode	> 30,000 FWHM
MS Sensitivity (ESI+)	120,000 counts/sec
MS Sensitivity (ESI−)	165,000 counts/sec
MS/MS Sensitivity	7,500 counts/sec

Pharmaceutical and Biopharmaceutical Analysis: The Xevo G3 QTof supports drug discovery and development through impurity profiling, metabolite identification, degradation studies, extractables and leachables analysis, and biotherapeutic characterization.
Proteomics and Metabolomics: Its high-resolution accurate-mass capabilities enable comprehensive protein characterization, peptide mapping, metabolite profiling, biomarker discovery, and systems biology research.
Food Safety and Agricultural Testing: The system is highly effective for screening pesticides, veterinary drug residues, food contaminants, adulterants, and naturally occurring toxins at trace levels.
Environmental Analysis: Researchers use the Xevo G3 QTof for the identification and quantification of emerging contaminants, industrial pollutants, PFAS compounds, pharmaceuticals in water, and other environmental pollutants.
Clinical and Biomedical Research: The instrument facilitates biomarker discovery, disease pathway investigations, translational research, and advanced omics studies requiring highly accurate molecular characterization.

By combining exceptional sensitivity, accurate-mass measurement, and advanced qualitative and quantitative performance, the system enables more comprehensive characterization of complex samples and trace-level compounds. This instrument enhances laboratory's ability to support pharmaceutical, biotechnology, food safety, environmental, and materials science projects with greater analytical confidence, faster turnaround times, and higher-quality data.

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