Association and Dissociation Constants

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Association constants (K_a) and dissociation constants (K_d) are useful indicators to describe the binding or affinity of drugs to binding sites. The association constant is a measure of the degree of reversible association between two molecular species in equilibrium. The dissociation constant is the rate constant of equilibrium dissociation. In pharmacology, the main factors affecting the dissociation constant are temperature and the presence of catalyst. Dissociation constant and association constant are reciprocals of each other in numerical value. They are very important properties of organic compounds, which determine the existence form of compounds in the medium, and thus determine their solubility, lipophilicity and other properties. For drug molecules, they also affect pharmacokinetic and biochemical properties.

Alfa Chemistry has a professional analysis team and advanced instrumentation to meet the pharmaceutical industry's various testing services, no matter at what stage your pharmaceutical research is, Alfa Chemistry can provide you with the most comprehensive testing services. Our experts can customize personalized testing services according to your requirements when you are confused. In addition to the determination of association and dissociation constants, we can also provide a wide range of services for the testing of pharmaceutical physical and chemical properties. Please feel free to contact us if you need any testing services in your pharmaceutical research.

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