Solubility
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Note: this service is for Research Use Only and Not intended for clinical use.
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water. Solubility is a major challenge for formulation scientist. Any drug to be absorbed must be present in the form of solution at the site of absorption. [1]
As a global leading pharmaceutical analysis services company, Alfa Chemistry provides solubility characterization of preclinical candidate and other preformulation analysis services. Alfa Chemistry is the perfect partner for getting expertise, flexibility, and reliability with your pharmaceutical formulation project.
Alfa Chemistry's solubility characterization services include:
pH solubility profile
Solubility in organic solvents
Solubility in Fasted State Simulated Intestinal Fluid (FaSSIF), Fed State Simulated Intestinal Fluid (FeSSIF) and Simulated Gastric Fluid (SGF)
Alfa Chemistry's instrument platforms:
µDISS Profiler Small Volume Dissolution and Solubility Apparatus
µSOL Evolution/EVO 96 High Throughput Miniaturized Shake Flask Solubility
µSOL Explorer Miniaturized Shake Flask Solubility
Gemini Profiler Ionization and Lipophilicity Analyzer
Our advantages:
Short Detection Cycle
Competitive Price
Years of Experience
Professional Equipment
Reliable Results
Compliance with Various Standards
Reference
Savjani, K. T., Gajjar, A. K., & Savjani, J. K. (2012). Drug solubility: importance and enhancement techniques. ISRN pharmaceutics, 1-10.
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