DynaPro Plate Reader 4

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Note: this service is for Research Use Only and Not intended for clinical use.

The DynaPro Plate Reader 4 is a high-throughput dynamic and static light scattering (DLS/SLS) system designed for rapid characterization of particle size, molar mass and sample stability directly in standard microwell plates. Unlike conventional cuvette-based light scattering instruments, the system performs measurements in situ without additional liquid handling, minimizing sample manipulation while allowing complete sample recovery after analysis.

Supporting automated workflows and multiple microplate formats, the DynaPro Plate Reader 4 enables efficient screening of large sample sets with precise temperature control, integrated visual inspection, and intuitive touchscreen operation, making it a valuable analytical platform for laboratories engaged in biomolecular and nanoparticle characterization.

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Key FeaturesApplications

Integrated DLS/SLS for simultaneous determination of particle size and molar mass.
High-throughput analysis using industry-standard 96-, 384-, and 1,536-well microplates, enabling efficient screening of large sample sets.
In situ measurements performed directly in microwell plates without additional liquid handling, preserving sample integrity and allowing complete sample recovery.
Hydrodynamic radius measurement range of 0.5–1,000 nm for characterization of proteins, polymers, nanoparticles, and emulsions.
High sensitivity with DLS detection of as little as 0.125 μg of 14.4 kDa lysozyme and SLS sensitivity of 1 mg/mL of 66.7 kDa BSA.
Precise temperature control from 4 °C to 85 °C for monitoring thermal stability and structural changes.
Integrated camera for automatic inspection of each well to identify bubbles, turbidity, or precipitation before measurement.
Touchscreen interface and DYNAMICS® software supporting experiment setup, heatmap visualization, comprehensive data analysis, customizable reporting, and optional 21 CFR Part 11 compliance.

The DynaPro Plate Reader 4 is widely used for the high-throughput characterization of biomolecules and nanoparticles in research and development laboratories. It supports developability and formulation screening of biotherapeutics, enabling rapid assessment of protein size, aggregation, and stability. The system is also well suited for lipid nanoparticle (LNP) characterization, providing insight into particle size uniformity and formulation stability. Additional applications include protein quality control prior to interaction studies, optimization of buffer conditions for protein purification and crystallization, evaluation of nanoparticle and polysaccharide processing conditions, and determination of critical micelle concentration (CMC) and critical micelle temperature (CMT) for surfactants and polymers. These capabilities make the instrument a valuable tool for pharmaceutical research, biotechnology, nanomaterials development, and life science laboratories.

The addition of the DynaPro Plate Reader 4 significantly enhances laboratory's capabilities in high-throughput particle and biomolecular characterization. By combining dynamic and static light scattering within a microplate-based platform, the system enables rapid analysis of large sample batches while minimizing sample consumption and manual handling. Integrated imaging, precise temperature control, and advanced analytical software further improve data quality and experimental efficiency. This capability delivers reliable characterization solutions for proteins, peptides, polymers, nanoparticles, emulsions, and other complex materials.

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