Immunochemistry Services

Through the immunochemistry analysis or large molecule bioanalysis, we can efficiently determine the product efficacy, safety, disease state or mechanism of action and gain the useful feedback data for supporting the important decisions during biologic drug development.

With decades of expertise in offering a wide variety of immunoassay-related services, scientists from Alfa Analytical Service have the extensive knowledge and enough capacity to conduct a reliable, sensitive, and specific immunoassay for our customers. Our top-notch experts and technique platforms enable a series of immunochemistry services can be provided, including but not limited to immunoassays, biomarker assays, cell-based neutralization assays, immunogenicity assays and ligand-binding assays. Additionally, with comprehensive suite of workflows, our laboratories are also competent to perform antibody purification, antibody characterization/quantification, antibody modification and labeling. Our industry-leading immunochemistry expertise will further provide developing and validating proprietary assays, implementing and validating existing methods, optimizing methods then validating, and also validating existing immunoassay kits (ELISA and ECL platforms) for supporting your toxicokinetics (TK) and pharmacokinetics (PK) studies, immunogenicity and biomarker studies.

We provide antibody services which include:

• Antibody Purification: With various antibody purification techniques and approaches such as HPLC purification, size exclusion chromatography, ammonium sulfate precipitation and Ion exchange chromatography, we can offer a high quality purification services for a wide array of proteins, including the routine protein A/G and the rare proteins such as protein L.

• Antibody Modification/bioconjugation: A suit of modification methods can be applied to support your needs for antibody modifications, antibody bioconjugations or antibody labeling. With various purification and modification techniques, our high-quality modification services include:

  Antibody Biopolymer Conjugation and Immobilization
  Antibody Fluorescent Labeling
  Secondary Antibody Detection Probes
  Antibody Enzyme Conjugation
  Antibody Liposome Conjugation
  Antibody Nanoparticle Labeling
  Antibody Immobilization
  Antibody Oligonucleotide Conjugation
  Antibody Fragmentation

• Antibody Characterization: Several techniques such as HPLC, SDS, PAGE IEF Analysis, ELISA and mass spectrometry are competent to perform the quantity, quality, and function of your antibodies produced.

• Antibody Immobilization: By coupling of your antibodies such as protein, peptide and antibodies to membranes, gel matrix or beads, a high standard quality of purification or quantitative analysis services will be offered by our experts. In addition, combined with the microarray printing technology and system integration, we can provide any printing services according to your needs such as printing on 3-D glass substrates, membranes or on other substrate.

• Assay Development: A variety of polyclonal antibodies and optimized protocols are suitable for your ELISA based assay development. As professional in developing the right antibody screening methods, we are capable of providing complete custom immunoassay services for your particular requirements.

Other immunochemistry services include:

• Quantitative Immunoassays: Utilizing various detection platforms such as ELISA, electrochemiluminescence (ECL) and radioimmunoassay (RIA) analysis, we offer our clients with accurate test results and verifiable and reproducible data.

• Biomarker Assays: Our dedicated biomarker assay experts can offer a wide range of biomarker services for supporting your biopharmaceutical development through techniques such as validated ELISA and MSD multiplex platforms.

• Cell-Based Neutralization Assays (NAb): Through the cell-based neutralization assays, we can gain the data of safety and efficacy of biologics.

• Immunogenicity Assays: Immunogenicity assays can be applied for detection and confirmation of anti-drug antibodies and neutralizing antibodies.

• Ligand-Binding Assays (LBA): Assessment of PK, TK and PD will be determined by LBA for supporting biologic preclinical and clinical development.

We are looking forward to discussing with you for your immunochemistry testing requirements and our excellent scientists will offer you the best balance between yield, purity and cost. Besides, the diversified service options in our laboratory can meet any special needs of clients. If any more detailed information about our immunochemistry services you want to know, I'd love to hear from you.