Polymer-drug Conjugates Analysis

Recombinant proteins, antibodies, peptides and other biomolecules have been used as effective therapeutic drugs. However, these biomolecules have some shortcomings in large-scale production and application, such as poor stability, non-specific targeting, fast clearance and so on. The delivery of these drugs through polymer-drug conjugates has been shown to successfully treat many diseases such as cancer, diabetes, AIDS, and so on. The advantages of using polymer-drug conjugates to deliver drugs include:

• Extending the half-life of the drug.

• Improving the solubility and stability of hydrophobic drugs.

• Enhancing drug specificity by adding targeting residues.

• Reducing the risk of adverse drug reactions.

Figure 1 Various polymer structures in polymer-drug conjugates¹.

However, the presence of covalent bonds may inhibit the activity of small molecular drugs, so polymer conjugation systems need to be tested to meet your needs. As a leader in biopharmaceutical analysis, Alfa Chemistry offers a comprehensive range of polymer-drug conjugate analytical services. We provide a range of state-of-the-art technology platforms and methods to provide accurate and reliable technical support for your testing services. Our experts can communicate with you one-on-one to develop customized solutions to verify the quality and safety of your products to meet regulatory requirements. For more information on polymer-drug conjugate analysis, please feel free to contact us.

Alfa Chemistry's polymer-drug conjugates analysis include but not limited to:

• Confirmation of secondary structure and polymerization

• Solubility detection

• Structural stability testing

• Identification of post-translational modification and binding sites

• Verification of validity of the conjugate

Alfa Chemistry's technology platforms include but not limited to:

• Multi-angle Light Scattering (MALS)

• Size Exclusion Chromatography

• Enzyme Linked Immunosorbent Assay (ELISA)

• Two-dimensional Difference Gel Electrophoresis (2-D DIGE)

• Hydrophobic Interaction Chromatography (HIC)

• Capillary Electrophoresis (CE)

• Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry (FTICR-MS)

• MALDI-TOF-MS

• ESI-QTOF-MS

• LC-MS/MS

Alfa Chemistry's advantages:

Reference

• Greco, Francesca & Vicent, María. (2008). 'Polymer-drug conjugates: Current status and future trends.' Frontiers in bioscience. 13(13): 2744-56.