NanoDSC

The Nano DSC differential scanning calorimeter is designed to measure the amount of heat absorbed or released by dilute in-solution bio-molecules as they are heated or cooled. Macromolecules such as proteins respond to heating or cooling by unfolding at a characteristic temperature. The more intrinsically stable the biopolymer, the higher the midpoint temperature of the unfolding transition. As these processes often exchange microjoule levels of heat, the sensitivity of the Nano DSC is critical for successful investigation of the reaction.

Applications

• Determination of thermal stability and heat capacity of proteins and other macromolecules in dilute solutions

• Investigation of Protein-Ligand Binding

• Characterization of Protein Structure

Strengths

• Highest sensitivity, lowest cell volume for unmatched performance

• Capillary cell design for analysis of samples that tend to aggregate or precipitate

• Built-in precision pressurizing system maintains accurate, constant pressure in the cells

• Solid-state thermoelectric elements for accurate temperature control during heating and cooling scans

• Upgradeable with industry proven HPLC grade autosampler for reliable high sample throughput