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- Physical and Chemical Characterization
Physical and Chemical Characterization
Online InquiryThrough our global network of testing experts and analytical equipment including chromatography (HPLC, GC, GC/MS) and atomic absorption spectroscopy (AAS, GFA, FIAS), Our goal is to provide test services as efficiently as possible to maximize our customers' profits. For more information about our services, contact one of our experts today.
Note: this service is for Research Use Only and Not intended for clinical use.
During the development of new drug substances, except focusing on biological characteristics, a broad range of physical-chemical properties must be determined to understand the behavior of drugs in physiological systems. Physical and chemical properties can affect drug performance and development of efficacious dosage form. Therefore, a complete physical and chemical characterization is the primary step for quality control in the pharmacy industry. Solid-state properties (such as solubility, particle size, and morphology) and solution properties (such as association and dissociation constants, solubility and stability) are both critical factors in the development of pharmaceutical formulations.
Alfa Chemistry owns expertise and is equipped with a complete suite of state-of-the-art instrumentation allow to carry out a precise physicochemical characterization of the drug product. Our experts work hard to provide you with a customized solution for your project to suit a variety of needs. We have extensive experience with a variety of product types, which includes:
Solid State Properties
Properties of solid drugs have an impact on all stages of drug development, from synthesis to production of clinical supplies, which affect the bulk properties, formulation performance, process ability, stability and appearance. Characterization of solid pharmaceutical is an area that needs to be focused on, it is particularly true when a solid drug is delivered in tablets or capsules. Through X-ray powder diffraction (XRD), thermal analysis (DSC and TG), solubility assay, scanning electron microscopy (SEM), spectroscopy, and solid state NMR, etc, Alfa Chemistry performs a variety of solid-state properties analysis.
Surface area
Particle size distribution
Polymorphism ? solid-state stability ? intrinsic dissolution rate
Solid-state stability
Intrinsic dissolution rate
Thermal analysis
Solution Properties
Pharmaceutical solutions may be defined as liquid preparations, in which the therapeutic agent and various excipients are dissolved in the chosen solvent system. Pharmaceutical solutions are extensively used as dosage forms for the oral administration. The properties of pharmaceutical solutions are very important property in drug discovery and development, which affects so many aspects of pharmacology (e.g., structure-activity relationships, efficacy, pharmacokinetics, toxicity). Alfa Chemistry carries out comprehensive studies to determine the solution properties as following:
Association and dissociation constants
Solubility as a function of pH
Partition coefficients as a function of pH
Solution thermodynamics
Complexation constants
Solubility in selected solvents
Solution stability
Compound Screening
Compound Screening is defined as a method used to discover specific compounds that could be promising candidates for pharmaceutical development. Compound Screening is also done to identify the potential side effects caused by administration of such compound(s). Alfa Chemistry has been a reliable provider of compound screening services in the areas of pre-clinical drug development programs.
Enantiomorphic composition
Partition coefficients at selected pH
Estimated dissociation constant
Alfa Chemistry is a company that offers pharmaceutical services, we focus on solving your problems with professional solutions through unique and state of the art technologies. Please feel free to contact us to learn more information.
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