Intrinsic Dissolution Rate

The solubility and dissolution rate of active ingredients are of major importance in preformulation studies of pharmaceutical dosage forms. The formulation characteristics including shelf life, process behavior and even the bioavailability are affected by physicochemical properties of drug molecules. The intrinsic dissolution rate (IDR) has been used to characterize solid drugs for many years. IDR is generally defined as the dissolution rate of a pure drug substance under the condition of constant surface area, agitation or stirring speed, pH and ionic strength of the dissolution medium. Dissolution plays a key role in defining bioavailability of the solid dosage forms, in particular those comprising drug substances of low aqueous solubility. It is therefore an integral part of preclinical and clinical development that includes screening and physicochemical characterization of active pharmaceutical ingredients (APIs) and product formulation work ideally resulting in the establishment of an in vivoin vitro correlation. Dissolution modeling is often used for Alfa Chemistry initio biopharmaceutical evaluations and in experimental gastrointestinal models to rationalize selection of formulation and dosage strengths. Dissolution testing also constitutes one of the most important analytical tools in the pharmaceutical industrial quality control (QC) laboratory. The analytical method development typically involves selection of dissolution apparatus, optimizing dissolution media and hydrodynamic conditions.

Alfa Chemistry provides intrinsic dissolution rate test services of drugs including tablets, pills, bulk agents and capsules, as well as solid pharmaceutical preparations. Our scientists have years of experiences in intrinsic dissolution rate analysis of drug. If you are looking for intrinsic dissolution rate test of drug based on basket type, paddle type, circular type and disintegrate type measuring instrument, we are here to help you. Alfa Chemistry will be your one-stop shop for all your intrinsic dissolution rate test and research.

Intrinsic dissolution rate test of drug

Searching for new drug substances is a complex process that needs to consider many pharmacodynamics and pharmacokinetic. The most distinctive problems related to the complexity of the drug development is a considerable growth of poorly soluble drug substances resulting in limited and variable bioavailability after oral administration. It has been reported that over 40% of currently marketed drugs and 75% of substances under development can be characterized as practically insoluble in water. Solid phase of drugs influences the quality and performance of a solid dosage form. Alfa Chemistry can provide intrinsic dissolution rate test of drug based on channel flow method, paddle method, and intrinsic dissolution methods(USP). The channel flow technique is possible to gain more information on the dissolution kinetics and mechanism at the tablet dissolution/surface medium interface due to the well-defined hydrodynamics in the channel. The intrinsic dissolution rate method is based on the idea that the dissolution area is kept constant during the whole measurement. It can provide valuable information about the physicochemical behaviour of the pure drug substance in the dissolution medium. The compacts formed from the drug powders can be tested by conventional dissolution analysis using the paddle dissolution apparatus.

Our intrinsic dissolution rate test of drug services include:

• Tablets

• Pills

• Bulk agents

• Capsules 

• Solid pharmaceutical preparations

Alfa Chemistry offers intrinsic dissolution rate test of drug services. Glad to hear your comments and look forward to cooperating with you.