Safety Assessment Testing

Chemical substances play vital role in almost all aspects of human lives. They may present risks to human health and the environment. For example, toxic compounds may pollute air, water, soil, and food, and accumulate in the human body just as Figure 1[1]. Risk assessment of chemical substances is an ever-developing discipline. Transparent and accurate risk assessments are necessary for enterprise to make wise risk management decisions.

Figure 1 Human exposure to chemical substances from environmental media and sources

The safety of consumer goods is a primary concern for all stakeholders in today's market. The validity derived from a risk assessment depends largely on the quality and accuracy of data. Alfa Chemistry can provide high quality toxicological risk assessments (TRA) to highlight potential adverse health risks associated with certain products. We offer TRA services for consumer products such as cosmetic, art materials ingredients that are manufactured and sold in a wide range of industries. Our toxicologists are highly skilled professionals trained in toxicology, regulatory affairs, chemistry, biochemistry, environmental chemistry, biology and engineering. All of our toxicological risks assessments are approved by certified toxicologists.

TRA services are offered in the following area:

• Evaluation of the toxicity of the individual chemical ingredients of the formulation used to manufacture the product:

• Each ingredient is assessed for its hazard or toxicity include acute/chronic toxicity, irritation (skin, eye, respiratory and mucous membrane), sensitization (dermal and respiratory), mutagenicity, carcinogenicity, and reproductive and developmental toxicity.

• Potential for synergistic or unpredictable adverse effects from the combination of ingredients in the formulation.

• Exposure considerations:

• Physical characteristics

• Accessibility(e.g. liquid components)

• Intended use

• Consideration of foreseeable misuse of the product

• Recommendations for product label warnings as necessary (e.g. California Proposition 65)

• Consumer Product Safety Commission (CPSC) Regulations

• Labelling of Hazardous Art Materials (LHAMA)

• Canada Hazardous Products (Toys) Regulations

• European Toy Regulations

• Canada Consumer Chemicals and Container (CCCR) Regulations

• European Cosmetic Regulations

• European Classification, Labelling and Packaging of Substances and Mixtures (CLP Regulation)

• REACH Chemical Safety Assessment (CSA)

Scientists and engineers in Alfa Chemistry can help you become a trusted and valued enterprise. You will have a comprehensive safety document that allows your product to meet regulatory requirements worldwide under our TRA service. No matter what your concern is, we are always ready to help. If you have any problems regarding safety assessment, please contact us without hesitation.

Reference

• Nielsen E, Qstergaard G, Larsen JC (2008) Toxicological Risk Assessment of Chemicals. 1-2.