Psoralea Corylifolia

Psoralea corylifolia, commonly known as Babchi in Ayurvedic medicine and Bu Gu Zhi in Traditional Chinese Medicine (TCM), is a significant plant in the realm of herbal remedies. Belonging to the Fabaceae family, this plant is native to regions across India, China, and other parts of Asia. Renowned for its extensive medicinal properties, the seeds and other parts of Psoralea corylifolia have been utilized for thousands of years.

Recent scientific studies conducted globally have delved into the diverse chemical constituents present in Psoralea corylifolia. The plant is rich in compounds such as coumarins, flavonoids, monoterpene phenols, benzofurans, glycosides, lipids, fatty acids, and volatile oils. These findings are supported by modern pharmacological research, which highlights the plant's wide-ranging biological activities. Psoralea corylifolia exhibits anti-inflammatory, antibacterial, antiviral, antioxidant, anti-tumor, and photosensitizing properties, alongside estrogen-like effects. Furthermore, it plays a beneficial role in the cardiovascular, nervous, immune, locomotor, and reproductive systems, presenting promising prospects for varied health applications.

Psoralen

Psoralen is a naturally occurring compound found in the seeds of Psoralea corylifolia and various other plants. As a furocoumarin, it has a unique capability to intercalate with DNA, subsequently inhibiting DNA synthesis and cell division. This compound is renowned for its immunomodulatory effects, particularly in influencing the Th2 immune response in vitro. Psoralen demonstrates potential in alleviating the degeneration of lumbar intervertebral discs that IL-1β induces and can also interact with the IL-1β signaling pathway.

Furthermore, Psoralen shows promise in overcoming multidrug resistance by inhibiting the expression of the ABCB1 gene and its associated protein. Notably, when used in combination with ultraviolet A, Psoralen serves as an effective treatment option for psoriasis, offering therapeutic benefits for managing this chronic skin condition.

Psoralidin

Psoralidin is a naturally occurring phenolic compound extracted from the seeds of the plant Psoralea corylifolia. This compound is recognized for its wide range of biological activities, including its significant antidepressant-like and anti-inflammatory effects. Furthermore, psoralidin exhibits potent anticancer and chemopreventive properties. It functions as a dual inhibitor of the enzymes COX-2 and 5-LOX. Additionally, psoralidin acts as an agonist for estrogen receptors ERα and ERβ.

In the context of breast cancer, psoralidin is known to inhibit the expression of iNOS induced by LPS by repressing the Syk-mediated activation of the PI3K-IKK-IκB signaling pathways. Moreover, it induces ROS-dependent DNA damage and promotes protective autophagy, mediated by NOX4, in cancer cells. Overall, psoralidin's diverse pharmacological properties make it a compound of interest for various therapeutic applications.

Bavachin

Bavachin is a naturally occurring flavonoid renowned for its inclusion in traditional medicine, predominantly sourced from the seeds and fruits of Psoralea corylifolia. It functions as a phytoestrogen, engaging with estrogen receptors ERα and ERβ, exhibiting activation with half-maximal effective concentrations (EC50) of 320 nM and 680 nM, respectively. As an inhibitor of cholesterol acyltransferase, bavachin shows promising therapeutic potential, particularly in the management of type 2 diabetes, by enhancing insulin signaling pathways. Furthermore, it has exhibited the capability to stimulate the genetic expression of Vascular Endothelial Growth Factor (VEGF) in peripheral blood, thereby facilitating fracture healing. Additionally, bavachin offers protective benefits for joint cartilage in osteoarthritis patients by mitigating inflammation through the inhibition of the IL-1β-induced IKK-IκBα-NF-κB signaling pathway. Moreover, it holds potential in reducing skin pigmentation by suppressing melanin production, further highlighting its diverse medicinal properties.

Alfa Chemistry is a trusted partner in the procurement of high-quality compounds derived from Psoralea corylifolia. Renowned for its proven track record, Alfa Chemistry has successfully supplied an extensive range of plant-derived products to researchers and industries worldwide. Committed to excellence, our company offers innovative solutions and reliable research services, ensuring that clients receive superior, cutting-edge support for their scientific endeavors.

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