Lycium Chinense

Lycium chinense, commonly known as the Chinese boxthorn, is a crucial species in the Solanaceae family, renowned for producing the celebrated goji berry or wolfberry. This plant holds a prominent place in traditional Chinese medicine due to its extensive therapeutic use. Historically, it has been utilized to treat various conditions, including nightsweats, pneumonia, cough, hematemesis, inflammation, and diabetes mellitus.

Phytochemical research on Lycium chinense has revealed a wide spectrum of chemical constituents that contribute to its medicinal properties. These components include alkaloids, cyclopeptides, lignans, anthraquinones, coumarins, flavonoids, terpenoids, and sterols. The plant's rich chemical profile highlights its importance and enduring relevance in both traditional and modern medical practices.

Kukoamine A

Kukoamine A (Kuk A) is a naturally occurring bioactive spermine alkaloid found in the root bark of Lycium chinense. It exerts various therapeutic effects, such as antioxidant, neuroprotective, anti-inflammatory, antidiabetic, anticancer, and cytoprotective activities. Kuk A particularly shows neuroprotective effects by inhibiting oxidative stress and apoptosis following whole-brain irradiation (WBI) in rats. It also prevents radiation-induced neuroinflammation and preserves hippocampal neurogenesis by inhibiting the activation of NF-κB and AP-1. Additionally, Kuk A attenuates insulin resistance and fatty liver by downregulating Srebp-1c.

Kukoamine B

Kukoamine B (Kuk B) is a spermine alkaloid derived from Lycium chinense, known for its antidiabetic, antioxidant, and anti-inflammatory properties. It serves as a potent dual inhibitor of both Lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA), which are key pathogenic molecules involved in the induction of sepsis. Consequently, Kukoamine B shows promise as a candidate for sepsis treatment. Additionally, Kukoamine B may help prevent various human neurodegenerative disorders and other conditions caused by oxidative stress. It has demonstrated protective effects against hydrogen peroxide (H2O2)-induced cell injury and potential mechanisms in SH-SY5Y cells, making it worthy of further investigation.

At Alfa Chemistry, we are committed to providing top-quality natural products and phytochemicals to both the research and industrial sectors. Our dedication to advancing scientific knowledge and promoting wellness aligns seamlessly with the unique bioactive properties of Lycium chinense.

Our extensive catalog offers a wide range of phytochemicals, including those derived from Lycium chinense. Researchers and healthcare professionals can depend on our high-purity compounds for their studies, ensuring they have reliable materials to explore therapeutic potentials. Experience the difference our expertise can make—contact us today!

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