Gardenia Jasminoides

Product List

Gardenia jasminoides, commonly referred to as Cape Jasmine or Gardenia, is a flowering plant native to East Asia, encompassing countries such as China, Japan, and Korea. Belonging to the Rubiaceae family, it is renowned for its fragrant white flowers and glossy evergreen leaves. The plant serves both ornamental and medicinal purposes, playing a significant role in traditional medicine systems, particularly in Chinese herbal medicine. Known as Zhizi in Chinese, the fruits of Gardenia jasminoides are highly esteemed for their medicinal properties. These fruits have been utilized for centuries in Traditional Chinese Medicine (TCM) to address a variety of ailments, thanks to their anti-inflammatory, analgesic, and antipyretic effects.

Remarkably, more than 162 compounds have been identified in Gardenia jasminoides, with iridoids such as genipin and geniposidic acid found in its fruit. The active compounds present in this plant hold promising potential for treating various health conditions, ranging from inflammation to neurological disorders.

Typical Active Ingredients

Genipin

Genipin is a highly regarded natural cross-linking agent with versatile applications in the fields of biochemistry and medicine. It is particularly effective in cross-linking proteins, collagen, gelatin, and chitosan, enhancing their structural stability and utility. Beyond its role in biopolymer modification, genipin serves as a regulatory agent in drug delivery systems and as a key raw material in the production of gardenia blue pigment. One of its remarkable features is its ability to activate the Epstein-Barr virus (EBV) lytic cycle, alongside acting as a cell-permeable inhibitor of uncoupling protein 2 (UCP2). Genipin is noted for its antimicrobial, antiviral, antitumor, and anti-inflammatory properties. It is utilized to enhance bile flow for liver disease management and is being explored for its potential in treating periodontal disease by preventing the expression of matrix metalloproteinases (MMPs) in lesions. Additionally, it exhibits an antithrombotic effect by suppressing platelet aggregation, showcasing its broad therapeutic potential.

Geniposide

Geniposide is a bioactive iridoid glycoside prominently found in the fruits of Gardenia jasminoides and various other medicinal herbs. This compound is renowned for its diverse pharmacological properties, including anti-diabetic, antidepressant-like, antioxidative, anti-apoptotic, antiproliferative, and neuroprotective effects. Acting as an agonist for the GLP-1 receptor, geniposide plays a crucial role in regulating the expression of antioxidative proteins such as HO-1 and Bcl-2. It achieves this by activating p90RSK through the MAPK signaling pathway in PC12 cells. Furthermore, geniposide exhibits potential in mitigating hepatic fibrosis by suppressing TGF-β1-induced epithelial-mesenchymal transition (EMT). It inhibits both the TGFβ/Smad and ERK-MAPK signaling pathways, underscoring its therapeutic potential in liver disease management.

Gardenin B

Gardenin B is a potent flavonoid derived from Gardenia jasminoides, renowned for its remarkable antiproliferative effects across various cancer cell lines, including lung, breast, colon, hepatic, and leukemia, as well as in keratinocytes. One of the key mechanisms by which Gardenin B operates is through the induction of cell death in human leukemia cells. This process is orchestrated via multiple caspases, yet it notably occurs without the involvement of reactive oxygen species. Additionally, Gardenin B has been identified as a strong inhibitor of the biochemical production of nitric oxide, further underscoring its potential as a therapeutic agent in cancer treatment.

Choose Alfa Chemistry

Alfa Chemistry is a trusted partner in the procurement of high-quality compounds derived from Gardenia jasminoides. Renowned for its proven track record, Alfa Chemistry has successfully supplied an extensive range of plant-derived products to researchers and industries worldwide. Committed to excellence, our company offers innovative solutions and reliable research services, ensuring that clients receive superior, cutting-edge support for their scientific endeavors.

Please kindly note that our products and services are for research use only.