Naringenin

Product Name: Naringenin
CAS No: 480-41-1
Catalog Number: ALPE-AM003
Specification: 98%
Analysis: HPLC
Formula: C15H12O5
Molecular Weight: 272.25
Appearance: White or Off-White Fine Powder

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Naringenin is a flavonoid belonging to flavanones subclass. Structurally, it contains 15-carbon-atom flavonoid skeleton, with three rings out of which, two benzene rings are linked to a three-carbon chain. Naringenin is mainly found in citrus fruits (grapefruit and oranges) and tomatoes. It is synthesized from the aromatic amino acid phenylalanine and is available in different conjugated forms, primarily as aglycone, neohesperidoside, and glycosylated forms ^[1]. Naringenin is considered to have bioactive properties such as antioxidant, anti-inflammatory, free radical scavenger, carbohydrate metabolism promoter and immune system modulater. This substance has also been shown to repair DNA damage.

• Cardiac Protection

Epidemiological and prospective studies have shown that naringenin has a certain cardioprotective effect, which may be related to its potential to act on calcium-activated potassium channels. Naringenin can reduce the area of myocardial infarction, reduce lactate dehydrogenase (LDH) in coronary effluent to increase regeneration capacity, and improve left ventricular function recovery. In addition, naringenin-treated myocardium has also exhibited an increase in superoxide dismutase (SOD) and a decrease in levels of malondialdehyde (MDA).

• Liver Protection

Naringenin is able to prevent liver injury caused by different agents. The main protective effects of naringenin in liver diseases are the inhibition of oxidative stress, the transforming growth factor (TGF-β) pathway and the prevention of hepatic stellate cell (HSC) transdifferentiation, which leads to reduced collagen synthesis ^[2].

• Anticancer

Naringenin has anticancer effects because it induces apoptosis and cell cycle arrest in a variety of cancer cell lines, including breast cancer cells, liver cancer, prostate cancer, melanoma, and glioblastoma of the brain and spinal cord.

• Anti-Diabetic

Naringenin has been found to have effective anti-diabetic potential, which is attributed to its ability to inhibit α-glucosidase and α-amylase ^[3]. This also suggests that naringenin has the potential to be a promising anti-diabetic alternative.

• Anti-Inflammatory

Naringenin has remarkable anti-inflammatory activity. It acts by inhibiting regulatory enzymes, altering arachidonic acid metabolism, regulating gene expression and influencing transcription factors that play an important role in the control of inflammatory mediators.

Naringenin is endowed with broad biological effects on human health. As a professional supplier of plant monomer, Alfa Chemistry is committed to providing customers with the most cost-effective naringenin under the premise of quality assurance. We are equipped with a professional R&D team to continuously learn the latest product knowledge and technology. If you have any need, please feel free to contact us.

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