Peucedanum Praeruptorum

Peucedanum praeruptorum, also known as Bai Hua Qian Hu in traditional Chinese medicine, is a flowering plant species belonging to the Apiaceae family. Its root has been employed for centuries in traditional Chinese medicine to treat various respiratory conditions such as cough, asthma, and pulmonary hypertension. The roots of Peucedanum praeruptorum exhibit a wide range of pharmacological activities including anti-inflammatory, neuroprotective, and antitumor effects, as well as properties that support bone health, combat depression, and inhibit osteoclastogenesis. Moreover, this plant is rich in a variety of beneficial phytochemicals, including simple coumarins, pyranocoumarins, furanocoumarins, flavonoids, ketones, sterols, and organic acids, among others.

Peucedanol

Peucedanol is a naturally occurring compound extracted from the roots of the Peucedanum praeruptorum plant. It has garnered attention for its potential antioxidant properties. In studies, peucedanol has demonstrated the ability to scavenge radicals, particularly the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, which indicates its efficacy in neutralizing harmful free radicals. Additionally, it shows promise in inhibiting the oxidation of liposomes when induced by 2,2'-azobis(2-amidinopropane) dihydrochloride. These properties suggest that peucedanol may play a beneficial role in protecting cells from oxidative stress, thereby contributing to maintaining cellular health and preventing oxidative damage.

Praeruptorin A

Praeruptorin A is a naturally occurring pyranocoumarin derived from the dried root of the plant Peucedanum praeruptorum. This compound is notable for its diverse pharmacological properties, offering neuroprotective, anti-osteoclastogenic, and anti-inflammatory benefits. In addition to its distinct relaxant effects, praeruptorin A plays a crucial role in facilitating nestin expression in cases of myocarditis, making it potentially effective in the early treatment of this condition. Research indicates that praeruptorin A can significantly enhance the expression of UGT1A1 in HepG2 cells, partly through a pathway mediated by the Constitutive Androstane Receptor (CAR). Furthermore, it has been shown to inhibit the p38/Akt-c-Fos-NFATc1 signaling pathway and prevent PLCγ-independent calcium oscillation, highlighting its complex mechanism of action.

Praeruptorin E

Praeruptorin E is an intriguing cardiotonic agent known for its selective agonistic effects on cardiac calcium channels. It has demonstrated the ability to relax the coronary arteries in swine, as well as reduce contractility in the left atria of guinea pigs. Beyond its cardiovascular benefits, praeruptorin E shows promise in respiratory medicine. It may offer therapeutic potential for treating lung injuries, as it has been observed to protect mice from damage induced by hydrochloric acid (HCl). This protective effect is achieved by inhibiting the influx of polymorphonuclear leukocytes (PMNs), reducing the release of interleukin-6 (IL-6), and minimizing protein exudation. Together, these actions position praeruptorin E as a possible candidate for addressing specific cardiac and pulmonary conditions.

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