Polydatin
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Polydatin

Polydatin

Product Name: Polydatin
CAS No: 65914-17-2
Catalog Number: ALPE-AM013
Specification: 98%
Analysis: HPLC
Formula: C20H22O8
Molecular Weight: 390.38
Appearance: White Powder

Description

Polydatin (also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, 3,4',5-trihydroxystilbene-3-β-d-glucoside) is a monocrystal-line compound, which was first isolated from the roots and rhizomes of Polygonum cuspidatum Sieb. et Zucc [1]. It also exists in a variety of other sources, including dietary plants such as grapes, peanuts and berries. Studies have shown that polydatin not only has a variety of important biological activities, including anti-inflammatory, anti-oxidant, anticancer, anti-microbial, neuroprotective, lung protective, hepatoprotective, but also has a certain role in health-promoting the renal system, respiratory system, rheumatoid diseases and skeletal system. With the deepening of research on Polygonum cuspidatum, it has been found that polydatin is a glycoside form of resveratrol, but it has a greater bioavailability than resveratrol.

Specification

ItemSpecification
Organoleptic
ColorWhite
OdorCharacteristic
AppearancePowder
Physical Characteristics
Particle Size100% pass 80 mesh
Loss on Drying≤5%
Methanol≤5%
Ethanol≤5%
Residue on Ignition≤3%
Heavy Metals
Total Heavy Metals<20 ppm
Arsenic (As)<2 ppm
Lead (Pb)<0.5 ppm
Cadmium (Cd)<1 ppm
Mercury (Hg)Not dectect
Microbiological Tests
Total Plate Count<1000 CFU/g
Total Yeast & Mold<100 CFU/g
E.coliNegative
SalmonellaNegative
StorageKeep in a cool & dry place. Stay away from moisture, light and oxygen.

Health Benefits

  • Inhibits Cancer Cell Growth

Polydatin has potential anticancer properties. For example, polydatin was found to induce apoptosis and inhibit the growth of acute monocytic leukemia cells [2]. Polydatin also inhibits the growth of lung cancer cells by inducing apoptosis and leading to cell cycle arrest [3].

  • Reduces Inflammation

Polydatin has a wide range of anti-inflammatory capabilities and can help reduce inflammation in the body. This can be beneficial for conditions involving chronic inflammation, such as arthritis and inflammatory bowel disease.

  • Treats Liver Disease

As a naturally occurring polyphenol, polydatin is commonly used in preclinical studies to protect and treat liver disease. It can treat liver diseases associated with oxidative stress through a variety of ways.

  • Improves Skin Health

The antioxidant properties of polydatin help to protect the skin from ultraviolet radiation and environmental damage. In addition, polydatin has been found to have anti-aging properties and therefore helps to improve the overall health of the skin.

  • Contributes to Neuroprotection

Polydatin has a certain neuroprotective effect. For example, studies have found that polydatin may counteract Alzheimer's disease, cognition/memory dysfunction, Parkinson's disease, brain/spinal cord injury, ischemic stroke, and other neuronal dysfunction [4].

Choose Alfa Chemistry

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin has attracted much attention due to its potential health benefits. As a professional supplier of plant monomer, Alfa Chemistry is committed to providing customers with the most cost-effective polydatin under the premise of quality assurance. We are equipped with a professional R&D team to continuously learn the latest product knowledge and technology. If you have any need, please feel free to contact us.

References

  1. Wu, M.; et al. Polydatin for treating atherosclerotic diseases: a functional and mechanistic overview. Biomedicine & Pharmacotherapy. 2020, 128: 110308.
  2. Wang, C.; et al. Polydatin induces apoptosis and inhibits growth of acute monocytic leukemia cells. Journal of Biochemical and Molecular Toxicology. 2016, 30(4): 200-205.
  3. Zhang, Y.; et al. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Oncology letters. 2014, 7(1): 295-301.
  4. Fakhri, S.; et al. The neuroprotective role of polydatin: neuropharmacological mechanisms, molecular targets, therapeutic potentials, and clinical perspective. Molecules. 2021, 26(19): 5985.

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