Gallium (III) nitrate, solution Ga 9-10% W/W

Application

Gallium (III) nitrate, a solution containing 9-10% weight by weight of gallium in nitrate form, serves a pivotal role mainly as a therapeutic agent introduced for tackling cancer-associated hypercalcemia and unmanageable bone metastases through adequate hydration. Its potent action on bone metabolism involves inhibiting calcium resorption and potentially encouraging bone formation, making it more effective and longer-lasting than treatments like calcitonin and etidronate. It's notable for its antitumor activity, especially against non-Hodgkin's lymphoma and bladder cancer, with low toxicity that sidesteps myelosuppression, a common drawback of conventional anticancer agents. In clinical contexts, gallium nitrate has shown utility not only in managing hypercalcemia but also in reducing bone turnover and osteolysis, which are common in patients suffering from multiple myeloma and various bone metastases. Beyond clinical applications, the gallium (III) nitrate solution is utilized in producing gallium salts, scientific research, and as a chemical reagent. As an oxidative agent, it is crucial to handle it with care, considering its potential reactivity, especially with reducing agents, which can lead to vigorous reactions and possibly explosive outcomes if not managed properly. Stability is afforded in certain conditions, confident in its solubility and compatibility with specific intravenous fluids and drugs, albeit with some exceptions.