Chloro(4-cyanophenyl)[(R)-1-[(S)-2-[bis(4-fluorophenyl]phosphino]ferrocenyl]ethyldi-tert-butylphosphine]nickel(II)

Application

Chloro(4-cyanophenyl)[(R)-1-[(S)-2-[bis(4-fluorophenyl]phosphino]ferrocenyl]ethyldi-tert-butylphosphine]nickel(II) serves as a versatile and cost-effective air-stable nickel catalyst, offering an alternative to palladium in carbon-carbon and carbon-heteroatom cross-coupling reactions. It is particularly effective in reacting substituted aryl and heteroaryl halides, as well as tosylates, with ammonia to yield a wide range of aryl and heteroaryl amines. The compound is utilized in monoarylation experiments employing commercially available ammonia gas, ammonium salts, or ammonia stock solutions. Additionally, it facilitates the coupling of aryl chlorides with gaseous amines when used in the form of their hydrochloride salts, and supports the amination of functionalized aryl chlorides with both ammonia and ammonium salts.