(20R)-Protopanaxatriol

General Information

• Product Name: (20R)-Protopanaxatriol
• Catalog: GINS-028
• CAS No.: 1453-93-6

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Description

(20R)-Protopanaxatriol, also known as PPT, is a naturally occurring triterpene found in plants of the genus Panax, particularly Panax ginseng. It belongs to the dammarane-type triterpenes, which have a unique chemical structure that gives them various properties. (20R)-Protopanaxatriol is primarily found in plants of the genus Panax, with Panax ginseng being one of the most abundant sources. Ginsenosides are bioactive compounds found in ginseng that can be metabolized to (20R)-protopanaxatriol in the human body. The pharmacological properties of (20R)-protopanaxatriol have been extensively studied. Studies have shown that it possesses a variety of biological activities, including anti-inflammatory, anticancer, neuroprotective, antioxidant, and immunomodulatory effects. These properties make (20R)-protopanaxatriol a promising compound for therapeutic applications.

Alfa Chemistry provides high-quality (20R)-Protopanaxatriol with the properties showed below:

Uses

• Anticancer Potential

One of the notable applications of (20R)-protopanaxatriol is its potential as an anticancer agent. Studies have shown that it is able to inhibit tumor growth and induce apoptosis in various cancer cell lines. It exerts its anticancer effects through multiple mechanisms, including regulation of cell cycle progression, inhibition of angiogenesis, and suppression of metastasis.

• Neuroprotective Effects

Neurodegenerative diseases pose a major challenge to modern healthcare. However, (20R)-protopanaxatriol has shown promising results in the field of neuroprotection. Studies have shown that it is able to protect neurons from oxidative stress, reduce neuroinflammation, and improve neuronal survival.

• Anti-inflammatory Activity

Inflammation plays a crucial role in the pathogenesis of various diseases. (20R)-protopanaxatriol exhibits potent anti-inflammatory properties by modulating key inflammatory pathways and inhibiting the release of proinflammatory cytokines.

Characteristics

• Solubility and Stability: (20R)-Protopanaxatriol has limited solubility in water but is soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Proper storage conditions must be maintained to ensure its stability and prevent degradation.
• Bioavailability and Metabolism: The bioavailability of (20R)-protopanaxatriol is affected by factors such as its formulation, route of administration, and interactions with other compounds. It undergoes metabolic transformation in vivo primarily through glucuronidation and sulfation processes. Understanding its metabolism is essential for optimizing its pharmacokinetic properties.
• Structure-Activity Relationship: The structure-activity relationship (SAR) of (20R)-protopanaxatriol plays a crucial role in determining its biological effects. Modifications to its chemical structure can affect its potency, selectivity, and pharmacokinetic properties. Researchers continue to explore SAR to develop derivatives with greater therapeutic potential.
• Formulations and Delivery Systems: Various formulations and delivery systems have been investigated to improve the efficacy and bioavailability of (20R)-protopanaxatriol. These include nanoformulations, liposomes, micelles, and solid lipid nanoparticles. These systems can improve drug delivery, target specific tissues or cells, and protect compounds from degradation.

Alfa Chemistry is committed to producing high-quality ginseng extracts and ginsenosides, based on high-end R&D and production equipment, supported by domestic and international biotechnology and scientific management team. For high quality products and more information, please feel free to contact us.

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