General Information
- Product Name: Ginsenoside Rg3
- Synonyms: 20(S)-Ginsenoside Rg3
- Catalog: GINS-015
- CAS No.: 14197-60-5
Inquire Now
Description
Ginsenoside Rg3 (G-Rg3) is a panaxadiol found in white and red ginseng with a hydrophobic four-ring steroid backbone connected to sugar molecules which are responsible for the hydrophilicity of the molecule. Based on the positioning of hydrogen on carbon 20 (C20), ginsenoside Rg3 has two stereoisomers, the 20(S) and 20(R) enantiomers. The Ginsenoside Rg3 is in the 20(S) form.
Ginsenoside Rg3 exhibits a broad range of biological in vitro and in vivo effects, including anticancer, antidiabetic, neuroprotective, antioxidant, anti-hypertensive, and anti-inflammatory actions, etc. Its anti-cancer mechanisms mainly include induction of apoptosis, inhibition of cell proliferation, metastasis and angiogenesis, as well as the promotion of immunity. In addition, Ginsenoside Rg3 can be used as an adjuvant to conventional cancer therapy. Furthermore, Ginsenoside Rg3 inhibits the 5-HT3A and α3β4 nACh receptors, the voltage-dependent Ca2+, K+, and Na+ channel currents. Ginsenoside Rg3 attenuates angiotensin II-induced cardiac hypertrophy by modulating the SIRT1/NF-κB pathway and inhibiting NLRP3 inflammasome and oxidative stress [1,2].
Alfa Chemistry provides high-quality Ginsenoside Rg3 with the properties showed below:
| Items | Specification |
| CAS No. | 14197-60-5 |
| Formula | C42H72O13 |
| Molecular Weight | 785.01 |
| Appearance | White to beige powder |
| Purity | 98+% |
| Storage | Keep in a refrigerated, sealed, dark place |
| Solubility | DMSO: 97 mg/mL |
| Shelf life | 3 years @ -20°C in powder
2 years @ 4°C in powder
6 months @ -80°C in solvent
1 month @ -20°C in solvent |
Alfa Chemistry is committed to producing high-quality ginseng extracts and ginsenosides, based on high-end R&D and production equipment, supported by domestic and international biotechnology and scientific management team. For high quality products and more information, please feel free to contact us.
References
- Nakhjavani, M., Smith, E., Townsend, A. R., et al. Anti-Angiogenic Properties of Ginsenoside Rg3. Molecules, 2020, 25(21), 4905.
- Ren, B., Feng, J., Yang, N., et al. Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway. International Immunopharmacology, 2021, 98, 107841.
Please kindly note that our products and services are for research use only.
