General Information
- Product Name: Ginsenoside Rf
- Catalog: GINS-011
- CAS No.: 52286-58-5
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Description
Ginsenoside Rf (G-Rf) is a trace ginsenoside among other diverse ginsenosides found in panax ginseng, which is classified as protopanaxatriol-type ginsenosides. Ginsenoside Rf is one of the biologically active saponins found in panax ginseng.
Ginsenoside Rf appears to be promising compound that could prove useful in anti-obesity, anti-nociceptive, anti-inflammatory treatments and it is a potential therapeutic agent for major depressive disorders. For instance, the treatment of Ginsenoside on 3T3-L1 adipocytes downregulates the expression levels of PPARg and perilipin, and also decreases the amount of lipid accumulated at different doses [1]. It has been proved that Ginsenoside Rf increases the mechanical withdrawal threshold significantly, with a curvilinear dose-response curve peaking at 1.5 mg/kg, and can decrease the lever of serum interleukin (IL)-1b, IL-6, and tumor necrotizing factor-α [2]. Other mechanisms may include inhibition of N-type Ca2+ channel, upregulation of glial fibrillary acidic protein (GFAP) expression and Ki-67 expression, and so on.
Alfa Chemistry provides high-quality Ginsenoside Rf with the properties showed below:
| Items | Specification |
| CAS No. | 52286-58-5 |
| Formula | C42H72O14 |
| Molecular Weight | 801.01 |
| Appearance | Solid |
| Purity | 98+% |
| Storage | Keep in a refrigerated, sealed, dark place |
| Solubility | DMSO: 100 mg/mL
Ethanol: 50 mg/mL |
| Shelf life | 3 years @ -20°C in powder
2 years @ 4°C in powder
6 months @ -80°C in solvent
1 month @ -20°C in solvent |
Alfa Chemistry is committed to producing high-quality ginseng extracts and ginsenosides, based on high-end R&D and production equipment, supported by domestic and international biotechnology and scientific management team. For high quality products and more information, please feel free to contact us.
References
- Siraj, F. M., Natarajan, S., Huq, M. A., Kim, Y. J., & Yang, D. C. Structural investigation of ginsenoside Rf with PPARγ major transcriptional factor of adipogenesis and its impact on adipocyte. Journal of Ginseng Research, 2015, 39(2), 141–147.
- Kim, M. K., Kang, H., Baek, C. W., et al. Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain. Journal of Ginseng Research, 2018, 42(2), 183–191.
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