General Information
- Product Name: Ginsenoside Rg2
- Catalog: GINS-014
- CAS No.: 52286-74-5
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Description
Ginsenoside Rg2 (G-Rg2) is a protopanaxatriol that is more abundant in some Panax species (e.g., white and red Panax ginseng) than others.
Ginsenoside Rg2 exhibits various biological activities including but not limited to anti-myocardial fibrotic, vascular dementia-ameliorating, glucose- and fat metabolism-improving, antioxidant, antidepressant effects, etc. via various mechaniams [1]. For instance, the protective effect of Ginsenoside Rg2 against DOX-induced toxicity is associated with decreased production of ROS, downregulation of p53, and increased Akt phosphorylation (see figure 1) [2]. In addition, Ginsenoside Rg2 can inhibit the proliferation, migration, and phenotypic transformation of vascular smooth muscle cells induced by platelet derived growth factor-BB (PDGF-BB)–which may contribute to its anti-atherosclerotic role. Furthermore, it inhibits VCAM-1 and ICAM-1 expressions and reduces Aβ1-42 accumulation.
Fig. 1 Pharmacological activities related to Ginsenoside Rg2
Alfa Chemistry provides high-quality Ginsenoside Rg2 with the properties showed below:
| Items | Specification |
| CAS No. | 52286-74-5 |
| Formula | C42H72O13 |
| Molecular Weight | 785.01 |
| Appearance | White Powder |
| Purity | 98+% |
| IC50 & Target | NF-κB, Aβ1-42 |
| Storage | Keep in a refrigerated, sealed, dark place |
| Solubility | DMSO: 50 mg/mL |
| Shelf life | 3 years @ -20°C in powder
2 years @ 4°C in powder
6 months @ -80°C in solvent
1 month @ -20°C in solvent |
Alfa Chemistry is committed to producing high-quality ginseng extracts and ginsenosides, based on high-end R&D and production equipment, supported by domestic and international biotechnology and scientific management team. For high quality products and more information, please feel free to contact us.
References
- Xue Q, Yu T, Wang Z, et al. Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis. J Ginseng Res. 2023 Mar;47(2):237-245.
- Qiu, B., Mao, M., Ma, Z. et al. Ginsenoside Rg2 Attenuates Doxorubicin-induced Cardiomyocyte Apoptosis via the PI3K/Akt Pathway. Rev. Bras. Farmacogn. 2022, 32, 433–439.
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