General Information
- Product Name: (20R)-Protopanaxadiol
- Catalog: GINS-026
- CAS No.: 7755-01-3
Inquire Now
Description
(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori. (20R)-Protopanaxadiol is a naturally occurring triterpene compound found in the roots of ginseng plants, particularly Panax ginseng. It belongs to the class of dammarane-type saponins, which are known for their pharmacological properties and health benefits. Protopanaxadiol has been studied for its various biological activities, including anti-inflammatory, anti-oxidant, anti-tumor, and neuroprotective effects. It has also been shown to have potential therapeutic applications in the treatment of cardiovascular disease, diabetes, and cognitive disorders. Due to its diverse pharmacological properties, (20R)-Protopanaxadiol is widely used in traditional medicine and herbal supplements. Research into its potential benefits continues to uncover its promising therapeutic potential in various health conditions.
Uses
- Anti-inflammatory effects
(20R)-Protopanaxadiol has been shown to possess anti-inflammatory properties, making it useful in the treatment of various inflammatory conditions such as arthritis, asthma, and inflammatory bowel disease.
Studies have suggested that (20R)-Protopanaxadiol may have anticancer properties, particularly in the treatment of lung, prostate, breast, and liver cancer.
(20R)-Protopanaxadiol exhibits antioxidant activity, which can help protect cells from oxidative damage and reduce the risk of chronic diseases such as heart disease and cancer.
Some research suggests that (20R)-Protopanaxadiol may help protect against neurodegenerative diseases such as Alzheimer's and Parkinson's disease by reducing oxidative stress and inflammation in the brain.
(20R)-Protopanaxadiol has been found to have cardioprotective effects, including reducing blood pressure, improving blood flow, and protecting against heart damage caused by ischemia-reperfusion injury.
(20R)-Protopanaxadiol may help modulate the immune system, making it potentially useful in the treatment of autoimmune diseases and enhancing the body's immune response to infections.
Some studies have suggested that (20R)-Protopanaxadiol may have anti-diabetic properties, including improving insulin sensitivity and reducing blood sugar levels in diabetic patients.
(20R)-Protopanaxadiol has been shown to have hepatoprotective effects, protecting the liver from damage caused by toxins, alcohol, and other harmful substances.
Alfa Chemistry provides high-quality (20R)-Protopanaxadiol with the properties showed below:
| Items | Specification |
| Cas | 7755-01-3 |
| Description | (20R)-Protopanaxadiol analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination. |
| Molecular Formula | C30H52O3 |
| Molecular Weight | 460.74 |
| SMILES | [H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@@](C)(O)CCC=C(C)C |
| Purity | (20R)-Protopanaxadiol analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.
Purity (HPLC) ≥95% |
| Safety | Precautionary statement P260: Do not breathe dust/fume/gas/mist/vapours/spray. P262: Do not get in eyes, on skin, or on clothing. |
| Storage | <-15°C. Store in dry and dark place. |
Alfa Chemistry is committed to producing high-quality ginseng extracts and ginsenosides, based on high-end R&D and production equipment, supported by domestic and international biotechnology and scientific management team. For high quality products and more information, please feel free to contact us.
References
- Li, Pengfei, et al. Systematic studies on the kinetic process of 20 (S)-protopanaxadiol in rats and dogs: absorption, distribution, metabolism and excretion. Frontiers in Pharmacology 15 (2024): 1430780.
- Han, Qingqing, et al. (20S)‐Protopanaxadiol Ginsenosides Induced Cytotoxicity via Blockade of Autophagic Flux in HGC‐27 Cells. Chemistry & Biodiversity 17.7 (2020): e2000187.
Please kindly note that our products and services are for research use only.
