Unnatural Amino Acid Modification

Unnatural amino acid modifications have a variety of applications in drug development, protein engineering, and chemical biology. By replacing the original amino acids with unnatural amino acids, many shortcomings of the peptide itself can be overcome. For example, unnatural amino acids can be used to improve the activity or selectivity of peptides and the plasma stability of peptides in new drug development. In addition, the use of unnatural amino acids can induce the formation of stable secondary structures. Alfa Chemistry provides reliable and efficient unnatural amino acid modification services to support our customers' research and development efforts, providing high-quality unnatural amino acid modified peptides that meet your exact specifications.

Our Services

We offer an extremely rich range of unnatural amino acid modifications, including D-amino acids, homo-amino acids, and other special amino acids. You can view detailed modification options in the table below. Other modification options not listed are also available upon request.

Why Choose Unnatural Amino Acid Modification?

• Enhance stability. Unnatural amino acid modified peptides are usually more resistant to proteolytic degradation, increasing their stability and bioavailability in biological systems.
• Improve binding affinity. Unnatural amino acid Modification can allow for the precise tuning of peptide structures, leading to enhanced binding affinity and specificity for their target molecules.
• Reduce immunogenicity. By incorporating unnatural amino acids, it is possible to reduce the immunogenicity of peptides, making them more suitable for therapeutic use in humans.
• Facilitate conjugation. Unnatural amino acids can be designed to contain functional groups that facilitate conjugation to other molecules, allowing for the creation of peptide-drug conjugates or targeted delivery systems.
• Increase diversity. The use of unnatural amino acids expands the diversity of peptide structures that can be synthesized, enabling the discovery of novel peptide-based therapeutics with unique properties.

Service Process