Bicyclic Peptide Synthesis

Bicyclic peptides are a class of peptides that contain two cyclic structures within their molecular framework. These peptides are known for their unique structural features, which can provide increased stability and activity compared to linear peptides. In addition, because bicyclic peptides have both the pharmacological properties of small molecules and the targeting properties similar to antibody drugs, they have received more and more attention in recent years, especially in the field of peptide drug conjugates (PDC). Alfa Chemistry has rich experience in bicyclic peptide synthesis and has served many domestic and foreign customers. With our team of experienced chemists and state-of-the-art equipment, we are able to provide high-quality bicyclic peptides for research and development purposes.

What We Offer

We offer a range of services related to bicyclic peptide synthesis to support our clients in advancing their research and development efforts in the field of peptide-based therapeutics and drug discovery. Our services include:

Synthesis Methods

Some common methods we use to synthesize bicyclic peptides include:

• Chemical synthesis. Chemical synthesis is the most common method for creating bicyclic peptides. In this approach, the two cyclic structural elements are typically synthesized separately and then joined together through a linker region. This can be achieved using solid-phase peptide synthesis (SPPS) or solution-phase peptide synthesis.
• Disulfide bond formation. Bicyclic peptides can also be synthesized through the formation of disulfide bonds. In this method, two linear peptide chains containing cysteine residues are first synthesized. The cysteine residues are then oxidized to form a disulfide bond, resulting in a bicyclic peptide structure.
• Ligation. Ligation is another method for synthesizing bicyclic peptides, where two linear peptide chains are linked together to form a cyclic structure. This can be achieved using chemical ligation methods such as native chemical ligation (NCL) or thiol-ene click chemistry.
• Cyclization. Bicyclic peptides can also be prepared through the cyclization of linear peptides. In this approach, the linear peptide is synthesized with specific amino acid residues that can undergo intramolecular cyclization, forming the two cyclic structural elements in the final bicyclic peptide.

Service Process