Peptoid Synthesis

Peptoids, also known as poly-N-substituted glycines, are a class of biomimetic oligomers. They are an exciting and versatile class of molecules that have gained significant interest in the fields of medicinal chemistry, materials science, and biotechnology. Peptoids are synthesized by a variety of methods, including solid-phase synthesis, solution-based synthesis, and microwave-assisted synthesis, allowing for the precise control of their structure and properties. With their unique characteristics and potential applications in drug discovery, biomaterials, and molecular recognition, peptoids have emerged as promising alternatives to peptides in various research areas. As a leading biotech company specializing in peptide and peptoid synthesis, Alfa Chemistry offer a wide range of peptoid synthesis services tailored to meet the diverse needs of our clients. Our expertise in peptoid synthesis allows us to provide custom-designed peptoids with precise control over sequence, length, and functionality. Contact us today to learn more about our peptoid synthesis services and how we can support your research efforts.

About Peptoids And Peptides

Peptoids are a class of biomimetic polymers that mimic the structure and function of natural peptides, with side chains attached to the nitrogen atoms of the peptide backbone rather than to α-carbon (as they are in amino acids). In natural peptides, the R groups represent 20 different substitutions of specific amino acids, whereas in peptoids, the choice of R groups can be much wider and potentially unlimited.

Fig.1 Structural comparison of peptoid and peptide

Our Services

Alfa Chemistry offer comprehensive peptoid synthesis services and ensure that each peptoid synthesized meets the highest standards of quality and purity. The specific service content is as follows.

Our available peptoid side chains include but are not limited to the following:

Peptoid Synthesis Methods

• Monomer method. This method is very similar to peptide solid-phase synthesis, but before synthesizing peptoids, all protected monomers need to be synthesized. The synthesis process of each protected monomer is tedious and time-consuming.
• Submonomer method. This method does not require α-amino-protected monomers. It is divided into two steps: acylation reaction and substitution reaction. In the acylation reaction, the haloacetic acid is first activated and then reacts with the amine remaining at the end of the previous step. The most common is to activate bromoacetic acid with diisopropylcarbodiimide. In the substitution reaction (the classic SN2 reaction), the amine replaces bromine to form N-substituted glycine. The submonomer synthesis method has great advantages over the monomer synthesis method and has been widely used in the construction of peptoid libraries. We currently synthesize peptoids using the submonomer approach.

Our Advantages

Service Process