Peptide Library Synthesis

Peptide library is a combination of a series of different peptides. In biological and chemical research, peptide library is a powerful screening tool. It is used to screen a very small number of peptides with key biological activities from a large number of peptides. Peptide library has a wide range of applications in the rapidly developing proteomics and related fields. Alfa Chemistry has mastered advanced peptide library synthesis technology and can provide personalized peptide library synthesis services according to the different application needs of customers.

Our Services

In order to meet your needs for different peptide library purities, we have developed two types of peptide library synthesis services, namely crude peptide library synthesis and purified peptide library synthesis.

* Delivery time refers to working days, and if the number of peptides is large, the synthesis time will be appropriately extended.

Peptide Library Types

We can design and synthesize the following 6 types of peptide libraries.

• Overlapping peptide library. Overlapping peptide library is mainly used for whole protein scanning, providing an ideal tool for screening linear or continuous epitopes. The design of overlapping peptide library is mainly determined by two parameters: peptide length and step number. It is designed from the N-terminus of the target protein to the C-terminus, transferring one or several amino acids each time, with partial overlap between sequences, and finally forming an overlapping peptide library.
• Alanine scanning peptide library. Alanine scanning peptide library is used to identify specific amino acid sites that are closely related to the function, stability and conformation of peptides. We use alanine to replace amino acids in the sequence one by one to identify the effect of a specific amino acid on the overall protein structure, function and other biological activities.
• Positional scanning peptide library. Positional scanning peptide library is an important tool for optimizing peptide sequences. By systematically replacing a selected region or site of the peptide with other amino acids, peptide sequences with better activity can be identified. This peptide library helps researchers find specific regions in the peptide that have special effects or activities.
• Truncation peptide library. Truncated peptide library is used to confirm the shortest amino acid sequence in the peptide sequence that plays an active role. It is generally obtained by systematically removing amino acids on both sides of the peptide sequence.
• Random peptide library. Random peptide library is obtained by random spontaneous substitution of 20 natural amino acids at selected sites using the "shotgun approach". The unique sequences generated by random peptide library have the potential to enhance the activity of peptides.
• Scrambled peptide library. Scrambled peptide library is a peptide library with high variability, which is constructed by rearranging and combining the original peptide sequence. Scrambled peptides are often used as negative controls to confirm that a specific sequence is the key to protein function or activity.

Application Areas of Peptide Library

Our peptide libraries can be used in the following fields. You can choose the type of peptide library you need according to your research field.