Peptide chelation modification refers to the modification of peptides by attaching chelating molecules to enhance their stability or interaction with metal ions. This modification is commonly used in various fields such as drug development, materials science and biochemistry. Alfa Chemistry specializes in providing peptide chelation modification services, utilizing state-of-the-art techniques and expertise to meet the specific needs and requirements of our clients. With our extensive experience and commitment to quality, we guarantee high-quality, reliable and cost-effective peptide chelation modification services for researchers and companies in need of tailored solutions.
Our Services
Alfa Chemistry offers a wide range of peptide chelation modifications to ensure optimal performance and functionality of the modified peptides. The commonly used chelators we offer are listed in the table below.
| Name | Abbreviation | Structure |
| 1,4,7,10-Tetraazacyclododecane-N,N,N,N-tetraacetic acid | DOTA |  |
| 1,4,7-Triazacyclononane-N,N,N-triacetic acid | NOTA |  |
| Diethylenetriaminepentaacetic acid | DTPA |  |
| 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid | TETA |  |
| 4,11-Bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane | CB-TE2A |  |
| 1,8-Diamino-3,6,10,13,16,19-hexaazabicyclo[6,6,6]-eicosane | DiAmSar |  |
Applications of Chelated Modified Peptides
Chelated modified peptides have a wide range of applications in various fields such as pharmaceuticals, biochemistry, and materials science. Some of the key applications include:
- Drug delivery. Chelation modification of peptides can enhance their stability and bioavailability, making them ideal candidates for drug delivery systems.
- Imaging. Chelated modified peptides can also be used as imaging agents for diagnostic purposes. By incorporating chelators that bind to specific imaging probes, these peptides can be used to target and visualize disease markers or specific tissues in the body. This can be particularly useful for non-invasive imaging techniques, such as positron emission tomography (PET) or magnetic resonance imaging (MRI).
- Targeted therapy. Chelated modified peptides can be designed to specifically target and deliver therapeutic agents to diseased cells or tissues, thereby improving the efficacy and reducing side effects.
- Diagnostic assays. Chelated peptides are utilized in diagnostic assays for detecting biomarkers, pathogens, or disease-specific targets.
- Materials science. Chelated modified peptides have potential applications in materials science. They can be employed in the synthesis of novel materials with unique properties such as catalytic activity, optical properties, and mechanical strength.
- Biosensors. Chelated modified peptides can be used to develop biosensors for detecting various biomolecules and analytes with high sensitivity and selectivity.
- Biological research. Chelated modified peptides are valuable tools for studying biological processes and interactions in the laboratory. They can help researchers track and study the behavior and distribution of biomolecules in the body. For example, chelated modified peptides can be used to probe protein-protein interactions, receptor-ligand binding, and other molecular interactions, providing insights into the mechanisms underlying various diseases. In addition, chelated modified peptides can also be used in the development of new therapeutic strategies or drug candidates.
Our Advantages
- Diverse modification types. We have a variety of chelators for customers to choose from to meet different downstream applications of customers.
- Rich experience. Our team have extensive experience in peptide chelation modification and can select the best modification scheme based on the sequence characteristics and downstream applications provided by the customer.
- High efficiency. We can complete the chelation modification of peptides in one to two weeks.
- Strict confidentiality. We strictly keep the customer's peptide sequence information confidential and never disclose any information about the customer's ongoing projects.
Service Process
