C-terminal Modification

C-terminal modification of peptides refers to the chemical alteration of the carboxylic acid group at the C-terminus of the peptide molecule. This modification can have profound effects on peptide structure and function, making them valuable tools for drug development, biochemical studies, and therapeutic applications. By modifying the C-terminus of peptides, researchers can tailor their properties to suit specific needs. Alfa Chemistry is committed to delivering reliable and efficient peptide C-terminal modification services to support our clients' research and development efforts. We are able to provide suitable C-terminal modification options based on your specific requirements and intended application.

Our Services

Alfa Chemistry provides a full range of peptide C-terminal modifications to meet your needs in different research fields. The table below shows some of the common C-terminal modification options we offer. Other C-terminal modification options are available upon request.

Why Choose C-terminal Modification?

• Improve peptide stability. C-terminal modification can enhance the stability of peptides by protecting them from enzymatic degradation, thus extending their half-life in biological systems and increasing their effectiveness in various applications. For example, adding an acetyl group to the C-terminus can prevent degradation by exopeptidases, enhance the stability of the peptide and extend its half-life in the body.
• Enhance peptide biological activity. C-terminal modification can lead to improved binding affinity, receptor specificity, and biological activity of the peptide, making it more effective in its intended application.
• Increase peptide solubility. C-terminal modification can also improve the solubility of peptides, making them easier to work with in various research and development applications. For example, converting the C-terminal carboxyl group to an amide group can improve solubility by reducing hydrophobic interactions, making the peptide more readily available for biological interactions.

Our Advantages

• Expertise. Our team of researchers and technicians have extensive experience in peptide chemistry and modification techniques. With their expertise, we can ensure that your peptides are modified accurately and efficiently.
• Fast. Our streamlined processes enable us to provide fast turnaround times for our C-terminal modification services.

• Flexibility. We provide a wide range of C-terminal modifications to suit the specific needs of each client's project. Whether you require amidation, esterification, aldehylation, or any other modification, we can tailor our services to meet your unique requirements.
• Cost-effectiveness. By outsourcing your peptide C-terminal modification to us, you can save time and resources. Our competitive pricing and efficient services offer a cost-effective solution for your research and development needs.

Service Process