N-terminal Modification

N-terminal modification of peptides refers to the chemical modification of the amino group at the N-terminus of the peptide molecule. This modification can involve the addition of various functional groups, such as acetyl, formyl, or myristoyl, or the removal of certain amino acids to generate a truncated peptide. N-terminal modification can be used to alter the properties of the peptide, such as increasing its stability, improving its solubility, or enhancing its binding affinity to a target molecule. Alfa Chemistry is committed to delivering reliable and efficient peptide N-terminal modification services to support our clients' research and development efforts. We are able to provide suitable N-terminal modification options based on your specific requirements and intended application.

Our Services

Alfa Chemistry provides a full range of peptide N-terminal modifications to meet your needs in different research fields. The table below shows some of the common N-terminal modification options we offer. Other N-terminal modification options are available upon request.

Why Choose N-terminal Modification?

• Enhance peptide stability. N-terminal modification can improve the stability of peptides by protecting them from degradation by enzymes in the body. For example, acetylation of the N-terminus of a peptide can protect it from proteolytic cleavage.
• Improve peptide pharmacokinetic properties. N-terminal modification can alter the pharmacokinetic properties of peptides, such as their half-life in the body, bioavailability, and distribution. For example, PEGylation, the attachment of polyethylene glycol to the N-terminus of a peptide, can increase its circulation time in the bloodstream.
• Regulate peptide biological activity. N-terminal modification can modulate the biological activity of peptides by altering their interactions with receptors, enzymes, or other proteins. Phosphorylation of the N-terminus of a peptide, for instance, can regulate its signaling pathways and cellular functions.

Our Advantages

• Expertise. Our team of researchers and technicians have extensive experience in peptide chemistry and modification techniques. With their expertise, we can ensure that your peptides are modified accurately and efficiently.
• Fast. Our streamlined processes enable us to provide fast turnaround times for our N-terminal modification services.

• Flexibility. We provide a wide range of N-terminal modifications to suit the specific needs of each client's project. Whether you require acetylation, formylation, amidation, or any other modification, we can tailor our services to meet your unique requirements.
• Cost-effectiveness. By outsourcing your peptide N-terminal modification to us, you can save time and resources. Our competitive pricing and efficient services offer a cost-effective solution for your research and development needs.

Service Process