Nanozymes With POD-like Activity-Product List

Cr⁶⁺ can not only adjusted the electronic structure of Ag atoms but also improved the geometric structure of the adsorbed intermediate, which resulted in the optimization of free energy and change of bond lengths in the catalytic reaction process, increasing the POD-like activity of Cal-CS/PEG/Ag.

Porous Co₃O₄ nanosheets exhibit excellent visual colorimetric detection performance.

Self-assembled manganese phthalocyanine (MnPc) nanoparticles exhibit shape-dependent POD-like catalytic activities.

Polyvinyl pyrrolidone (PVP) modified Ru nanozyme exhibits extremely high POD‐like specific activity.

Polyvinyl alcohol (PVA) modified Ru nanozyme exhibits extremely high POD‐like specific activity.

Polyacrylic acid (PAA) modified Ru nanozyme exhibits extremely high POD‐like specific activity.

2D cobalt hydroxide oxide nanosheets exhibit superior reactive oxygen species (ROS) scavenging properties and can protect cells from oxidative damage.

The structure of Hemin@BSA@ZIF-8 is similar to horseradish peroxidase (HRP), in which hemin served as the active cofactor surrounded by BSA as a blocking pocket to construct a favorable hydrophobic space for substrate enrichment. Benefiting from the confinement effect, ZIF-8 with a porous intracavity was regarded as the ideal outer layer for Hemin@BSA@ZIF-8 to accelerate substrate transport and significantly enhance its POD-like activity.

Hemin@Ftn possesses high POD catalytic activity and high tolerance to the harsh environmental conditions, such as high temperature and chemical denaturant. This protein-based nanozyme bridges the gap between natural enzymes and nanomaterial-based nanozymes by the incorporation of a catalytically active prosthetic group into a highly stable Ftn.

Polystyrene sulfonate (PSS) modified Ru nanozyme exhibits a POD‐like specific activity of up to 2820 U·mg⁻¹.

The carbon dots confined in N-doped carbon (CDs@NC) can readily act as POD-like nanozyme, and its POD-like activity can be tuned easily by adjusting the content of glucose precursors.

The introduction of Ni improves the conversion efficiency between Fe³⁺ and Fe²⁺, promotes the generation of hydroxyl radicals, and thereby enhances the POD activity of Fe_xNi_y-MOF.

Due to its ultrathin nanosheet structure and high density of Cu active sites, with a Cu loading of up to 14.3 wt%, carbon nitride-supported Cu single-atom nanozyme (Cu/CN) exhibits POD-like activity and excellent catalytic performance.

The Co atom site can cooperatively affect the d-band center position of the Fe atom site and serve as the second reaction center, which makes Fe₁Co₁-NC nanozyme have better POD-like activity.

Mo_SA-N_x-C single-atom nanozyme has superior and exclusive POD-like activity, and the POD-like specificity is well regulated by the coordination numbers of single Mo sites.

Defect-rich CoFe-layered double hydroxides (d-CoFe-LDHs) nanosheets have lower H₂O₂ adsorption energy, which promotes the decomposition of H₂O₂, thereby effectively enhancing the POD-like activity.

Boron-induced charge transfer effects can adjust the positive charge of the central Fe atom to reduce the energy barrier of the formation of hydroxyl radical, thereby boosting the POD-like activity of FeBNC single atom nanozyme (SAzymes).

IrOx-GOD can convert the over-expressed H₂O₂ at tumor tissue to O₂, and O₂ could further react with continuous supplied glucose to produce gluconic acid and H₂O₂ by GOD, achieving continuous supply of O₂ and H₂O₂.

Au@HCNs have a typical yolkdshell structure in which an Au nanoparticle core is encapsulated within a hollow carbon nanospheres with porous shell. The Au@HCNs perform high POD-like and oxidased-like activity enzyme functions due to the cooperative effect of Au nanoparticles and the carbon shell in the yolkdshell structure.

Cu_2-xTe nanoparticles exhibit tunable enzyme-mimic activity including POD and glutathione oxidase under near-infrared-II (NIR-II) light.

Ir-N₅ SA is a single-atom nanozyme composed of a single iridium atom and five nitrogen atoms and has a variety of enzyme-like catalytic activities including POD-like, catalase (CAT)-like, oxidase-like and NADH oxidase (NOX)-like activities.

BiO_2-x nanosheets exhibit POD-like and CAT-like activities. The oxygen vacancies generated in BiO_2-x nanosheets are beneficial to the adsorption of H₂O₂ and increase the carrier density for the production of ROS. In addition, BiO_2-x nanosheets also have excellent acoustic and thermal effects.

Taking advantage of the good charge transfer and synergistic effects between gold, platinum, and cobalt elements, AuPtCo nanozymes exhibit strong catalytic activity. AuPtCo nanozymes can catalyze the Chemiluminescence (CL) emission in a flash type after reacting with the substrate N-(4-Aminobutyl)-N-ethylisoluminol (ABEI) and the oxidant H₂O₂.

Fe₃O₄@Pt@E5 exhibit POD-like, CAT-like and oxidase activities. It has uniform morphology and small size, and has good stability and biocompatibility.

Prussian blue nanozymes can effectively scavenge ROS via multi-enzyme activities including POD-like activity, CAT-like activity and superoxide dismutase (SOD)-like activity. Prussian blue nanozymes can be used as new antioxidant and anti-inflammatory materials, and can also be used in the fields such as drug loading, photothermal therapy, etc.

Fe₃O₄ nanozymes exhibit triple enzyme-like activities including POD, CAT, and SOD, thus potentially possessing the ability to regulate the ROS level.

SiO₂@MPGs exhibit POD and SOD activities. Their thermal stability is better than molecular enzyme mimics and natural horseradish peroxidase (HRP).

The CoMo hybrids exhibit triple enzyme-like activities including POD-, CAT- and oxidase-like activities. In addition, the CoMo hybrids is also reproducible, stable and reusable, that is, after 10-cycle uses, >90% mimic enzyme activity of the CoMo hybrids is still maintained.

2D Cu-TCPP(Fe)/GOD have good catalytic performance. Among them, GOD can effectively convert the glucose into abundant gluconic acid to self-activate the POD-like activity of the nanosheets, and meanwhile the considerable amount of generated H₂O₂ can be used for the subsequent catalysis of the nanosheets.

MOF_-Au-Ce have dual enzyme-like activities. On the one hand, the MOF doped with Au (MOF_-2.5Au) showed enhanced POD-mimetic activity, which was potent for antibacteria. On the other hand, the Ce complexes grafted to MOF revealed admirable DNase-mimetic activity to catalyze hydrolysis of eDNA.

R-CMs are a series of defect-rich adhesive nanozymes that have inherent bacterial capturing and efficient antibacterial characteristics. With abundant rough surfaces formation and defect-rich edge sites exposure, they could fast trap bacteria within the scope of elevated ROS destruction.

MoS₂ nanozymes possess both intrinsic POD-like activity and highly photothermal conversion efficiency in the NIR region. They covalently linked to hydrogel can achieve synergistic antibacterial effects.

The ZIF is a flower-like nanozyme with highly permeable leaflets accommodating catalytic metal sites. The cobalt single-atom/cluster sites in its highly porous matrix generated POD/oxidase-like activities with high catalytic efficiency up to 6 orders of magnitude greater than that of conventional nanozyme/biozymes.

DFMC exhibits POD-like activity under acidic conditions, catalyzing the decomposition of H₂O₂ into hydroxyl radicals. This process also promotes the formation of lipid peroxides. In addition, the nanozyme can also effectively consume glutathione (GSH), thereby enhancing ROS-mediated tumor catalytic therapy.

The ZIF-8 matrix protects the carbon dots (CDs) from aggregation and quenching, and the synergistic effect of CDs and ZIF-8 promotes electron transfer, giving the CDs@ZIF-8 excellent POD-like activity.

PCF-a NEs exhibite a cascade POD and glutathione peroxidase mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property and high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis.

GOD/hemin/DHA@ZIF-8 exhibit POD-like, GOD, glutathione peroxidase (GPx)-like activities. SufficientH₂O₂ was supplied in time via GOD-mediated glycolysis, which sustained the generation process of toxic hydroxyl radicals. Moreover, hemin (Fe³⁺) acted as not only peroxidase producing hydroxyl radicals, but also GPx consuming antioxidant GSH.

The highly active pyrite nanozymes overcome the problem of low affinity of traditional peroxide nanozymes for H₂O₂ and can catalyze limited H₂O₂ in tumor sites to generate a large amount of hydroxyl radicals. At the same time, the glutathione oxidase activity of pyrite nanozymes, not only provides substrate H₂O₂ for their POD activity, but also catalyzes the oxidation of GSH, causing cellular iron death, thereby achieving apoptosis-ferroptosis synergistic treatment of tumors. Importantly, the pyrite nanozymes can achieve efficient and safe tumor treatment effects as a single material without any other help, indicating that it has great potential for clinical translation.

BSA@AuNCs have intrinsic POD-mimetic effect, and based on the inhibition of their POD-mimetic effect, nanosensor chemiluminescent (CL) probe for sensing GSH can be developed.

RuO₂ NPs catalytic properties mimic the activity of POD, CAT, SOD and GPx. In addition, RuO₂ NPs show excellent antioxidant activity and low biological toxicity. And the nanozyme can be efficiently and rapidly absorbed by human embryonic kidney cells while significantly reducing ROS-induced apoptosis by eliminating excess ROS.

Copper hexacyanoferrate (Cu-HCF) nanozyme possesses active single-site copper and exhibits cascade enzymatic activity (i.e., POD and glutathione oxidase) within tumor microenvironment.

Cu_1.5Mn_1.5O₄ CFNSs exhibit enhanced triple enzyme activities, namely POD, oxidase and GPx, which can significantly enhance the production of ROS and effectively kill bacteria. In addition, Cu_1.5Mn_1.5O₄ CFNSs also exhibit excellent biosafety.

PEG/Ce-Bi@DMSN exhibit dual enzymemimic catalytic activities (i.e., POD- and CAT-mimic activities) under acidic conditions that can regulate the tumor microenvironment, that is, simultaneously elevate oxidative stress and relieve hypoxia. In addition, the nanozymes can effectively consume the overexpressed GSH through redox reaction.