Nanozymes With GPx-like Activity-Product List

VN₄ single-atom nanozyme exhibits ultra-high GPx-like activity, which is seven times higher than that of natural enzymes. It also has biocatalytic stability for several months and can be used dozens of times without significant degradation, indicating extremely high reusability and recyclability.

MIL-47(V)-X MOF (MIL stands for Materials of Institute Lavoisier) nanozyme not only has good biocompatibility, but also has excellent in vitro antioxidant ability in reducing ROS level, which can protect cells from oxidative damage. Further, they have anti-inflammatory properties against ear inflammation and colitis.

PtCu₃ nanocages can mimic GPx, which play an important role in accelerating glutathione (GSH) depletion by oxidizing molecules, further weakening the capacity of tumor cells scavenging ROS by GSH. In addition, PtCu₃ nanocages can act as horseradish peroxidase-like nanozymes, catalyzing the decomposition of H₂O₂ into hydroxyl radicals under acidic conditions for chemodynamic therapy (CDT).

PCF-a NEs exhibite a cascade GPx and peroxidase (POD) mimicking activities in circumneutral pH. In addition, PCF-a NEs exhibit photothermally augmented POD property and high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis.

GOD/hemin/DHA@ZIF-8 exhibit GPx-like, POD-like and GOD activities. SufficientH₂O₂ was supplied in time via GOD-mediated glycolysis, which sustained the generation process of toxic hydroxyl radicals. Moreover, hemin (Fe³⁺) acted as not only peroxidase producing hydroxyl radicals, but also GPx consuming antioxidant GSH.

RuO₂ NPs catalytic properties mimic the activity of GPx, POD, CAT and SOD. In addition, RuO₂ NPs show excellent antioxidant activity and low biological toxicity. And the nanozyme can be efficiently and rapidly absorbed by human embryonic kidney cells while significantly reducing ROS-induced apoptosis by eliminating excess ROS.

Cu_1.5Mn_1.5O₄ CFNSs exhibit enhanced triple enzyme activities, namely GPx, POD and oxidase, which can significantly enhance the production of ROS and effectively kill bacteria. In addition, Cu_1.5Mn_1.5O₄ CFNSs also exhibit excellent biosafety.

V₂O₅@pDA@MnO₂ nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant defense procedure in which GPx, superoxide dismutase (SOD), catalase (CAT), etc. It exhibited excellent intracellular ROS removal ability to protect the body against oxidative stress, showing its potential application in inflammation therapy.

Mn₃O₄ nanozyme functionally mimic three major antioxidant enzymes, namely GPx, SOD and CAT, and the multienzyme activity is size as well as morphologydependent. It can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.

Ultrasmall SnFe₂O₄ nanozyme exhibits GPx-like activity, which can scavenge overexpressed glutathione (GSH) and weaken the antioxidant capacity of tumors. In addition, it also has CAT-like activity and can react with hydrogen peroxide to generate oxygen to alleviate severe hypoxia in tumors. Under 808 nm laser irradiation, SnFe₂O₄ nanozyme can also produce photothermal therapy (PTT) and photodynamic therapy (PDT) efficacy. Combined with CT and magnetic resonance (MR) imaging functions, SnFe₂O₄ nanozyme can more accurately monitor the treatment process, showing great potential for synergistic therapeutic effects.

Ultrasmall copper based nanoparticles (Cu_5.4O USNPs) have the distinctive advantages of the ultrasmall particle size, rapid renal clearance, high biocompatibility and broad reactive oxygen species (ROS) scavenging abilities. Cu_5.4O USNPs simultaneously possessing CAT-, SOD- and GPx-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu_5.4O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu_5.4O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.

Cu-TCPP MOF nanodots possess GPx-like activity, which could be used as a powerful enzymecooperative platform to defend cell components from severe oxidative stress. They also have biomimetic size, the similar metal active sites coordination environment to natural SOD and the ordered channels akin to the substrate channels, exhibiting efficient SOD-like activity and can be used to alleviate endotoxemia.