Copper-Based Nanozymes-Product List

Ultrasmall copper based nanoparticles (Cu_5.4O USNPs) have the distinctive advantages of the ultrasmall particle size, rapid renal clearance, high biocompatibility and broad reactive oxygen species (ROS) scavenging abilities. Cu_5.4O USNPs simultaneously possessing catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu_5.4O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu_5.4O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.

Copper oxide nanozymes have glucose oxidase-like activity, which can be used to catalyze the oxidation of glucose with oxygen and produce H₂O₂. They can be used for chemodynamic therapy and starvation treatment of tumors.

A light-induced ultrasmall chiral nanozymes, chiral copper (I) sulfide (Cu₂S) nanoparticles, can recognize and cleave the HBV core antigen (HBcAg) by photonic excitation at 808 nm, thereby inhibiting the assembly of HBV. The discovery of the light-induced ultrasmall chiral nanozymes provides a good candidate strategy and a new insight for the development of antivirus.