Cancer Treatment - Nanozymes / Alfa Chemistry

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Cancer Treatment

Introduction

Cancer Treatment

According to the latest global cancer statistics from the World Health Organization/International Cancer Center team, cancer is expected to become the main cause of death in countries around the world in twenty-first century. Compared with traditional cancer treatment methods (surgery, radiotherapy, etc.), external minimally invasive or non-invasive strategies containing photodynamic therapy (PDT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), photothermal therapy (PTT), immunotherapy, etc. show a favorable development prospect due to their accurate tumor specifcity, space/time controllability and biosafety. However, the complex tumor microenvironment (TME) limited the therapeutic efects of many of the above methods. Nanozymes can regulate TME via changing reactive oxygen species (ROS) content or eliminating hypoxia. Therefore, they are widely used in the above-mentioned external minimally invasive or non-invasive treatment strategies. Furthermore, nanozymes possess high and tunable enzyme-like activity and good biocompatibility, further demonstrating their potential in cancer treatment.

Applications

Cancer Treatment Applications

Nanozymes can be used in PDT, CDT, SDT, PTT, immunotherapy, etc. for cancer treatment. They have shown highly effective therapeutic effects on many cancers, such as pancreatic cancer, liver cancer, lung cancer, prostate cancer, breast cancer, intestinal cancer, bladder cancer, etc. For example, Liu et al. developed a PTT enhanced nanozyme. It not only has photothermal effects, but also has light-enhanced peroxidase (POD)-like and catalase (CAT)-like activities in the tumor microenvironment, which can be used for deep pancreatic cancer treatment^[1]. Besides, nanozymes are also used in synergistic cancer treatment. For example, Au₂Pt nanozymes as POD and CAT mimics, have potent photothermal performance and can be used for PDT/CDT/PTT synergistic cancer therapeutics. AgPd nanozymes with POD-like activity can improve photothermal conversion efficiency, and have been proved to be acted as carriers for chemotherapeutic drugs transmission during a weakly acidic environment, thus achieving ROS/PTT/chemotherapy guided by NIR laser. Pt-CuS Janus nanozymes have photothermal conversion capacity under laser irradiation, and can decompose endogenous H₂O₂ expeditiously, and are adopted in synergistically enhanced SDT and PTT. The Pt nanozymes with CAT-mimicking capacity and Ru-Te hollow nanorods with oxidase (OXD), POD-, CAT- and superoxide dismutase (SOD)-like activity both act as carriers and relieve tumor microenvironment (TME) hypoxia to enhance cancer PDT/PTT effect.

Alfa Chemistry offers a wide range of nanozymes, which can be used for photodynamic, chemodynamic, sonodynamic and photothermal cancer treatment. We will offer the most suitable nanozymes according to customer's detailed requirements. At the same time, we also offer product customization. If you have any questions or needs, please don't hesitate to contact us. Alfa Chemistry will provide you with the most professional service.

Reference

Liu, H. Y.; et al. A nanozyme with photo-enhanced dual enzyme-like activities for deep pancreatic cancer therapy. Angew. Chem., Int. Ed. 2019, 58(36), 12624-12631.

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