Cerium-Based Nanozymes-Product List

CeO₂@MMT nanozymes combine the CeO₂ nanozyme with ROS elimination activity and the negatively-charged montmorillonite (MMT) to achieve the complementary advantages of each component. CeO₂ nanoparticles grown in situ on MMT sheets confer ROS scavenging activity to the MMT sheets, while the MMT sheets significantly minimize the systemic absorption of CeO₂ nanoparticles and thus reduce their potential nanotoxicity. CeO₂@MMT nanozymes have high ROS scavenging activity and high stability in the digestive tract, and have shown excellent improvement ability in the dextran sulfate sodium (DSS)–induced mouse inflammatory bowel disease model.

Cerium vanadate nanozyme has high superoxide dismutase (SOD) activity and can catalyze the conversion of superoxide into hydrogen peroxide and oxygen under physiological conditions. So cerium vanadate nanozyme can prevent the mitochondrial damage in cytosolic SOD and mitochondrial SOD-depleted cells by regulating the superoxide levels, thereby restoring the mitochondrial function and regulating the ATP levels. Besides, cerium vanadate nanozyme can also restore the functions of the crucial anti-apoptotic Bcl-2 family proteins under oxidative stress conditions.

Cerium oxide nanozymes (CeNZs) can effectively scavenge ROS in impaired hepatocytes for detoxification. More importantly, CeNZs can generate abundant oxygen based on their catalase (CAT)-mimic activity, thus further alleviating hypoxia and specifically inhibiting the pro-inflammatory macrophages to relieve inflammation for a promoted hepatocyte regeneration of drug-induced liver injury (DILI), which is vital for the treatment of late stage DILI when there is already massive hepatocyte necrosis. The dual detoxification and inflammatory regulation by CeNZs for DILI treatment suggesting the future clinical use of CeNZs for DILI treatment.

Photolyase activity CeO₂ nanozymes exhibit high activity and selectivity. They can resist UV damage to the skin, which will have great application prospects in medicine or beauty.

Zeolitic imidazolate framework-8-capped ceria nanoparticles (CeO₂@ZIF-8 NPs) overcome the drawbacks of CeO₂ NPs and achieve the following advantages: (i) The surface ZIF-8 acts as peroxidase to maintain the antioxidant activity in the presence of excessive H₂O₂ or other oxidants, which can absorb H₂O₂ and destroy the O-O bond to disintegrate H₂O₂. (ii) The ZIF-8 frame growing on the outer layer of CeO₂ NPs controls the size, shape, and surface charge of CeO₂ core to make it more suitable for biological application. (iii) The decomposition of ZIF-8 results in the release of active components, which synergistically enhance the stroke therapeutic efficacy of CeO₂. CeO₂@ZIF-8 NPs exhibit effective ROS scavenging in vitro. They also suppresses inflammation- and immune response-induced injury by suppressing the activation of astrocytes and secretion of proinflammatory cytokines, thus achieving satisfactory prevention and treatment in neuroprotective therapy.