Iron-Based Nanozymes-Product List

Prussian blue nanozymes can effectively scavenge ROS via multi-enzyme activities including peroxidase (POD)-like activity, catalase (CAT)-like activity and superoxide dismutase (SOD)-like activity. Prussian blue nanozymes can be used as new antioxidant and anti-inflammatory materials, and can also be used in the fields such as drug loading, photothermal therapy, inflammatory tissue imaging and construction of biosensor devices.

The highly active pyrite nanozymes overcome the problem of low affinity of traditional peroxide nanozymes for H₂O₂ and can catalyze limited H₂O₂ in tumor sites to generate a large amount of hydroxyl radicals. At the same time, the glutathione oxidase activity of pyrite nanozymes, not only provides substrate H₂O₂ for their peroxidase activity, but also catalyzes the oxidation of glutathione, causing cellular iron death, thereby achieving apoptosis-ferroptosis synergistic treatment of tumors. Importantly, the pyrite nanozymes can achieve efficient and safe tumor treatment effects as a single material without any other help, indicating that it has great potential for clinical translation.

Iron oxide nanozymes have pH-dependent POD-like, CAT-like and SOD-like activities, especially under acidic conditions, they can efficiently catalyze hydrogen peroxide to generate hydroxyl radicals, and have antibacterial and tumor cell killing functions.

Fe₃O₄ magnetic nanoparticles not only have excellent POD-like catalytic activity, but also have magnetic separation, magnetic resonance imaging, magnetic induction tumor hyperthermia, drug loading, magnetic targeting, long-acting sustained-release iron supplementation, promoting macrophages M1 type and M2 type transformation, promoting bone tissue repair and other functions.

Metal ferrite nanozymes include MnFe₂O₄, CoFe₂O₄, NiFe₂O₄, ZnFe₂O₄, MnZnFe₂O₄ nanozymes. The biomedical applications of metal ferrite nanozymes mainly include magnetic targeted therapy and biosensing.

FeN₃P-centered single-atom nanozyme (FeN₃P-SAzyme) controls the electronic structure of the single-atom iron active center through precise coordination of phosphorus and nitrogen, showing catalytic activity and kinetics similar to natural enzymes. In particular, the designed FeN₃P-SAzyme has tunable geometric structure and electronic structure and exhibits horseradish peroxidase (HRP) activity.

Fe-N-C single atom nanozymes (Fe-N-C SAzymes) have HRP activity. They can activate O₂ into •O₂⁻ and trigger some oxidation reactions. Fe-N-C SAzymes are applied in biosensor areas.