Bioimaging - Nanozymes / Alfa Chemistry

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Bioimaging

Introduction

Bioimaging Introduction

Bioimaging is an important research tool for understanding the structure of biological tissues and elucidating various physiological functions of organisms. Through different imaging methods, researchers can see the functions and structures of organs, tissues, and cells at different depths. Traditional bioimaging uses molecular probes to track targets and image them. Although molecular probes have been used in bioimaging for many years, the imaging contrast provided by these types of molecular probes is insufficient and they are usually only used to provide a single imaging mode. Based on the weaknesses of molecular probes, researchers have begun to develop new functional materials as imaging probes. The unique physicochemical properties of nanozymes, such as luminescence, X-ray absorption, and paramagnetic properties, make them become excellent imaging probes. In addition, nanozymes also have good chemical stability and are easily excreted by the body. Therefore, they are widely used in the field of bioimaging.

Applications

As important imaging probes, nanozymes can image living cells, tissues and organs, and thus have been widely used in bioimaging. In addition, with the advancement of science and technology, imaging technology continues to innovate. Nanozymes have been widely used in fluorescence imaging, magnetic resonance imaging, photoacoustic imaging, ultrasound imaging, thermal imaging, etc. For instance, graphene quantum-dot-based nanozyme is an ideal contrast agent for photoacoustic imaging, which is used for H₂O₂-responsive catalytic photoacoustic imaging of a xenograft nasopharyngeal carcinoma^[1]. Manganese oxide nanozyme with superoxide dismutase-like activity is a potent contrast agent for magnetic resonance imaging. They can rapidly catalyze the removal of superoxide radicals. When exposed to superoxide radicals, manganese oxide nanozyme significantly enhance magnetic resonance imaging contrast. Due to the unique combination of superoxide dismutase-like activity with enhanced magnetic resonance imaging contrast, manganese oxide nanozyme can be used as selective clinical magnetic resonance imaging tool^[2].

Besides, nanozyme-based multimodality imaging probes have also been widely developed, benefiting from the multifunctional properties of nanozymes. For instance, iridium oxide nanozymes have catalase-like activity, extraordinary photothermal conversion efficiency, and a high X-ray absorption coefficient. As imaging probes, they can achieve tumor phototherapy and simultaneous photoacoustic/thermal imaging and computed tomography^[3]. Prussian blue nanozymes could efficiently catalyze the decomposition of overexpressed H₂O₂ to O₂ in tumor tissues, in this way, the nanozyme-based system was able to change oxidative stress-induced acoustic impedance and enhance the signal of ultrasound imaging. In addition, Prussian blue nanozymes could also serve as magnetic resonance imaging probes owning to their unique properties and structures. Based on this, Prussian blue nanozyme can realize ultrasound and magnetic-resonance dual modality imaging of H₂O₂ in living system^[4].

Alfa Chemistry offers a wide range of nanozymes, which can be used as imaging probes and have been widely used in bioimaging. We will offer the most suitable nanozymes according to customer's detailed requirements. At the same time, we also offer product customization. If you have any questions or needs, please don't hesitate to contact us. Alfa Chemistry will provide you with the most professional service.

References

Ding, H.; et al. Exosome-like nanozyme vesicles for H₂O₂-responsive catalytic photoacoustic imaging of xenograft nasopharyngeal carcinoma. Nano Lett. 2019, 19, 203-209.
Tremel, W.; et al. Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast. J. Mater. Chem. B. 2016, 4, 7423-7428.
Zhen, W. Y.; et al. BSA-IrO₂: Catalase-like nanoparticles with high photothermal conversion efficiency and a high X-ray absorption coefficient for anti-inflammation and antitumor theranostics. Angew. Chem. 2018, 130, 10466-10470.
Gu, N.; et al. A hydrogen peroxide-responsive O₂ nanogenerator for ultrasound and magnetic-resonance dual modality imaging. Adv. Mater. 2012, 24, 5205-5211.

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