Individual Living Cell Encapsulation - Nanozymes / Alfa Chemistry

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Individual Living Cell Encapsulation

Introduction

Individual living cells encapsulation plays an important role in protecting cell viability and function. In order to still provide good protection in harsh environments, a growing effort has been devoted to developing powerful coating shells for individual living cells encapsulation, for example, silica, calcium phosphates, polymers, etc. But these coating shells have limited protecting abilities against toxic chemicals such as reactive oxygen species (ROS), which may cause oxidative stress on intracellular components and even lead to cell death. Additionally, they often require strong stimulation to decompose, which can cause severe damage to cells. To solve the above problems, nanozymes with cytoprotection function against harsh environments have been developed as biodegradable coating shells. Nanozymes have good biocompatibility and can regulate ROS levels, thereby reducing intracellular oxidative stress. Therefore, nanozymes are ideal coating shell materials for the individual living cells encapsulation. In the future this may be a general strategy to protect a variety of living cells.

Applications

With the in-depth study of nanozymes, their applications in individual living cell encapsulation have been developed. They are used as coating shell materials for the encapsulation of individual living cells, and can be used to encapsulate single living cells of microbial cells such as yeast, chlorella, and E. coli, as well as mammalian cells. For example, Qu and Ren's groups successfully achieved powerful individual living cell encapsulation for long-term cytoprotection and manipulation by using manganese dioxide (MnO₂) nanozymes as intelligent shells. They used a biomineralization method to mineralize MnO₂ directly on the surface of living individual yeast cells. Utilizing the superoxide dismutase and catalase properties of MnO₂ nanozymes, nanozyme-based shells can not only improve cells' tolerance to many physical factors such as dehydration and lytic enzymes, but also protect cells from harmful chemical factors for a long time. This strategy can be applied to other cell encapsulation and regulation^[1].

Fig.1 The formation and removal of MnO₂ nanozyme shells on individual living cells.

Alfa Chemistry can offer a wide variety of nanozymes, which can be used as coating shells for individual living cells encapsulation. We will offer the most suitable nanozymes according to customer's detailed requirements. At the same time, we also offer product customization. If you have any questions or needs, please don't hesitate to contact us. Alfa Chemistry will provide you with the most professional service.

Reference

Qu, X. G.; et al. Manganese dioxide nanozymes as responsive cytoprotective shells for individual living cell encapsulation. Angew. Chem., Int. Ed. 2017, 56, 13661-13665.

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