Nanozymes With SOD-like Activity-Product List

Red emissive carbon dots have SOD-like activity up to 4000 U·mg⁻¹. They can effectively enter cells, remove harmful reactive oxygen species (ROS), and protect cells from oxidative damage.

HA/Pt/Qu nanogel can remove ROS generated by light excitation in situ through the SOD-like properties of Pt NPs, thereby reducing phototoxicity, maintaining the integrity of the lysosome structure and further achieving efficient and low-toxic live cell fluorescence imaging.

Cerium vanadate nanozyme can catalyze the conversion of superoxide into hydrogen peroxide and oxygen under physiological conditions. So cerium vanadate nanozyme can prevent the mitochondrial damage in cytosolic SOD and mitochondrial SOD-depleted cells by regulating the superoxide levels, thereby restoring the mitochondrial function and regulating the ATP levels.

The IC50 of MnPS₃ is 3.61 μg·ml^-1, up to 12-fold lower than most reported SOD-like nanozymes. Moreover, a MnPS₃ microneedle patch can be used to treat androgenetic alopecia that could diffuse into the deep skin where hair follicles exist and remove excess ROS.

Gly-Cu(OH)₂ nanoparticles (NPs) are readily dispersible in aqueous media and can catalyze the decomposition of superoxide. Due to their extraordinarily high SOD activity, Gly-Cu(OH)₂ NPs incorporate in cigarette filters efficiently removed toxic ROS radicals from cigarette smoke.

NiO nanoflowers (NFs) could catalytically scavenge O₂^•- into O₂ and H₂O₂, exhibiting intrinsic SOD-like activity. NiO NFs have appropriate redox potential and can cycle between the Ni^II and Ni^III oxidation states, thereby displaying the SOD-like activity.

Mn-doped ZnS quantum dots (QDs) exhibit intrinsic SOD-like activity. They have low cost, good biocompatibility, and are easy to synthesize. Mn-doped ZnS QDs are expected to be used as a new type of SOD nanozymes in the biology-relevant fields.

PZIF67-AT is a nanozyme-based H₂O₂ homeostasis disruptor. With highly SOD-like activity, inhibiting catalase (CAT) activity, and depleting glutathione (GSH) ability, the disruptor could interfere with H₂O₂ homeostasis through accelerating the production and restrain the elimination of H₂O₂, leading to the elevation of the H₂O₂ level in cancer cells.

Cu-TCPP MOF nanodots have biomimetic size, the similar metal active sites coordination environment to natural SOD and the ordered channels akin to the substrate channels, exhibiting efficient SOD-like activity and can be used to alleviate endotoxemia. They also possess glutathione peroxidases (GPx)-like activity, which could be used as a powerful enzymecooperative platform to defend cell components from severe oxidative stress.

2D cobalt hydroxide oxide nanosheets exhibit superior reactive oxygen species (ROS) scavenging properties and can protect cells from oxidative damage.

Prussian blue nanozymes can effectively scavenge ROS via multi-enzyme activities including peroxidase (POD)-like activity, CAT-like activity and SOD-like activity. Prussian blue nanozymes can be used as new antioxidant and anti-inflammatory materials, and can also be used in the fields such as drug loading, photothermal therapy, inflammatory tissue imaging and construction of biosensor devices.

Fe₃O₄ nanozymes exhibit triple enzyme-like activities including POD, CAT, and SOD, thus potentially possessing the ability to regulate the ROS level.

SiO₂@MPGs exhibit POD and SOD activities. Their thermal stability is better than molecular enzyme mimics and natural horseradish peroxidase (HRP).

RuO₂ NPs catalytic properties mimic the activity of SOD, POD, CAT and GPx. In addition, RuO₂ NPs show excellent antioxidant activity and low biological toxicity. And the nanozyme can be efficiently and rapidly absorbed by human embryonic kidney cells while significantly reducing ROS-induced apoptosis by eliminating excess ROS.

V₂O₅@pDA@MnO₂ nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant defense procedure in which SOD, CAT, GPx, etc. It exhibited excellent intracellular ROS removal ability to protect the body against oxidative stress, showing its potential application in inflammation therapy.

Mn₃O₄ nanozyme functionally mimic three major antioxidant enzymes, namely SOD, CAT and GPx, and the multienzyme activity is size as well as morphologydependent. It can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.

MOF-818 have high SOD and CAT activities, which can scavenge ROS at wound sites. In addition, they also have good biocompatibility.

Ultrasmall copper based nanoparticles (Cu_5.4O USNPs) have the distinctive advantages of the ultrasmall particle size, rapid renal clearance, high biocompatibility and broad reactive oxygen species (ROS) scavenging abilities. Cu_5.4O USNPs simultaneously possessing SOD-, CAT- and GPx-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu_5.4O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu_5.4O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.