Nonclinical Evaluation

A fundamental objective of nonclinical evaluation is to understand the potential adverse effects of the oligonucleotide therapeutic candidate to support clinical development. Alfa Chemistry has a professional non-clinical pharmacology and toxicology research technology platform, which can carry out pharmacodynamic study, pharmacokinetic study, and safety evaluation. In addition to the common considerations of the design of general pharmacological and toxicological studies, such as selection of relevant rodent and nonrodent species, route of delivery, and dose levels/exposure profile, we are also focused on the special consideration for oligonucleotide therapeutics, including the assessment of exaggerated pharmacology and potential use of surrogate molecules specific to the selected toxicology species.

Over the years, we have paid close attention to all the adverse effects caused by oligonucleotide therapeutics. Treating patients' diseases without creating new troubles is our greatest vision. So, interested in our nonclinical pharmacological and toxicological studies? Please click the link below to learn more.

Pharmacodynamic Study

Pharmacodynamics is the study of how drugs affect living organisms. It includes in vivo pharmacodynamic and in vitro pharmacodynamic studies.

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Pharmacokinetic Study

Adsorption, distribution, metabolism, and excretion (ADME) of oligonucleotide therapeutics in the human body are important components of nonclinical studies.

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Safety Evaluation

Genotoxicity, immunotoxicology, reproductive toxicity, and safety pharmacology are the main focuses of oligonucleotide therapeutic safety evaluation.

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Our products and services are for research use only and cannot be used for any clinical purposes.

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