Liquid-Solid Coupled Synthesis

To meet the rising demand for high-purity oligonucleotides, the development of efficient, scalable, and cost-effective synthesis methods has become crucial. One of the emerging concepts is liquid-solid coupled synthesis, which combines the advantages of both liquid-phase and solid-phase synthesis approaches to enhance yield, reduce costs, and streamline purification.

Combining Liquid Phase and Solid Phase Techniques

The traditional solid phase oligonucleotide synthesis (SPOS) has been the dominant method for synthesizing oligonucleotides since the 1980s. In SPOS, the growing oligonucleotide chain is anchored to an insoluble support, typically resin, which simplifies the washing and separation steps between chemical reactions. This method has the advantages of high efficiency, fast, strong controllability and simple operation. In contrast to SPOS, liquid phase oligonucleotide synthesis (LPOS) is performed entirely in solution. As with conventional organic synthesis, the scalability of the process is unlimited and the number of reagents required can be reduced by performing the reaction in a homogeneous solution. Thus, the method has the advantages of a low monomer feed ratio, reduced solvent usage, easy purification, and strong scalability.

The liquid-solid coupled synthesis of oligonucleotides provides new possibilities for the efficient synthesis of oligonucleotides by combining the strengths of both SPOS and LPOS. It helps to meet the complex application needs of modern oligonucleotides in biotechnology and therapeutics.

What We Offer

Alfa Chemistry is a leading biotechnology company specializing in the synthesis of high-quality oligonucleotides. Based on liquid-phase molecular synthesis technology, our company is dedicated to the development of novel liquid-solid coupled synthesis technologies and production processes. By integrating the strengths of both liquid-phase and solid-phase synthesis methods, we strive to provide optimized, cost-effective solutions that meet the growing demands of the biotechnology and pharmaceutical industries.

Our expertise ensures the delivery of precise, high-purity oligonucleotides tailored to the specific needs of our clients, driving innovation across various sectors. If you have any need, please feel free to contact us.

Our products and services are for research use only and cannot be used for any clinical purposes.

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