Oligonucleotides usually contain between 10 and 30 nucleotides, but researchers can modify their length to suit specific needs. Alfa Chemistry delivers services for oligonucleotide synthesis to clients. Our synthesis services deliver fast and reliable results for both short and long chain oligonucleotides tailored to meet the demands of genetic engineering breakthroughs, drug discovery advances and diagnostic research innovations.
* Our products and services are for research use only and cannot be used for any clinical purposes.
Customized Synthesis
Provide oligonucleotide synthesis from small scale to large scale according to customer's specific needs.
High-quality assurance
Using advanced synthesis technology and strict quality control standards to ensure the purity and activity of each batch.
Rapid Delivery
Efficient production process ensures delivery of your needs in the shortest possible time.
Cost-effective
Reasonable price system to ensure the best cost performance.
Oligonucleotides are short nucleic acid chains made from DNA, RNA, or a combination of both. They function as essential instruments within biological research and pharmaceutical industries while facilitating numerous applications such as gene therapy and PCR amplification. For example, oligonucleotides are commonly used as primers in PCR to selectively amplify a target DNA sequence. They can also be labeled with fluorescent dyes or radioisotopes for detection. They are not only fundamental tools in molecular biology research but are also used in more complex clinical therapies such as cancer, genetic diseases, and the development of antiviral drugs.
Our holistic approach is designed to provide customized services that meet your unique research needs. Through a range of advanced technologies and precise synthesis processes, we are able to ensure high-quality oligonucleotides for your biological research.
We offer a full range of DNA oligonucleotide synthesis services to meet a variety of needs, from basic research to clinical applications. Whether it is simple sequence synthesis or complex modification and labeling, we provide high-quality DNA oligonucleotide products for a variety of research, diagnostic, OEM, and therapeutic applications.
Customized DNA oligonucleotides:
DNA oligonucleotide modification options:
Our custom RNA oligonucleotides can be designed to meet your specific requirements and include a wide range of modification and labeling options to ensure that your research, diagnostic, therapeutic and other application needs are met. Our RNA oligonucleotides are available in synthesis lengths of up to 300 bases, ensuring ease of use in a wide variety of research applications. We offer flexible RNA synthesis scales based on customer needs, suitable for small-volume research to large-scale production.
Oligonucleotide synthesis building blocks are the basic components of building oligonucleotides. They play a key role in ensuring both the integrity and functionality of the final oligonucleotide product. Alfa Chemistry offers a range of high purity oligonucleotide synthesis building blocks to meet the stringent requirements of modern research and biotechnology applications.
We offer a variety of efficient and customized oligonucleotide bioconjugation services to help you achieve precise molecular design and application. Each conjugation process is tailored to your research or product needs, ensuring efficient and precise bioconjugation reactions to meet various application requirements.
Naked or unmodified oligonucleotides, due to their high molecular weight and negative charge, are not only highly susceptible to nuclease degradation and poor membrane permeability but also trigger varying degrees of off-target effects and/or immunogenicity. Alfa Chemistry provides chemical modification of oligonucleotides to provide chemical modification services and technical advice to customers.
Oligonucleotide synthesis involves the chemical construction of nucleotide segments that possess specific chemical sequences. We employ a variety of cutting-edge platforms to support our comprehensive oligonucleotide synthesis capabilities. Each platform offers unique benefits based on application requirements, production scale, and the level of customization needed.
Alfa Chemistry also offers some ready-made oligonucleotide products. If you are interested, please click to view our product list.
Confirmation of customer requirements
Communicate with the customer to confirm the synthesis target and technical requirements.
Sequence design and confirmation
Design and confirm the sequence according to customer requirements.
Synthesis and purification
Adopt advanced technology for efficient synthesis and ensure purity through multiple purifications.
Quality control
Strict quality control, including HPLC, mass spectrometry, and other tests, to ensure that the product meets the requirements.
Delivery
Ensure on-time delivery of products required by customers.
Easily place an order online, choose your desired oligonucleotide sequence, quantity, and synthesis requirements, and we will personalize the process according to your needs.
Target gene silencing through specific oligonucleotide design, applied to the treatment of cancer and genetic diseases.
For PCR amplification and gene chip technology to help early screening and precise diagnosis of diseases.
To help develop mRNA vaccines against viruses, bacteria, and other pathogens.
Develop new antibodies or antigens through specific oligonucleotide sequences.
Have questions about ordering custom oligonucleotides from Alfa Chemistry? We collected answers to the most common oligonucleotide questions we received throughout the years for your convenience.
What approaches do you use to maintain the quality standards and purity levels of oligonucleotide batches?
To maintain the quality of every batch, we use sophisticated methods, including HPLC and mass spectrometry. The utilized methods make sure the product purity exceeds 99% while fulfilling your high standards for experimental accuracy and reliability.
How long will it take to receive synthesized oligonucleotides?
The standard delivery window for orders ranges from 5 to 10 business days based on order complexity and volume. Our expedited services are available for urgent orders to reduce delivery time.
Is your company capable of synthesizing large volumes of oligonucleotides in bulk?
Of course! Our services extend to both single small-scale orders and extensive large-scale synthesis projects. Our services support both small experimental needs and large production runs through adaptable capacity solutions.
Is your synthesis process reliable enough to achieve accurate results for complex sequences?
Our extensive experience in oligonucleotide synthesis enables us to employ advanced techniques for creating complex sequences. Our synthesis processes undergo stringent validation methods to maintain both accuracy and reliability. Our technical team will give personalized advice to help you meet specific requirements.
What purification methods do you offer?
Our purification options include HPLC purification methods and Polyacrylamide Gel Electrophoresis (PAGE) purification techniques. The purification techniques we employ eliminate synthesis-generated contaminants to satisfy your product purity standards.
What steps do you take to manage impurities or errors when performing synthesis?
Our quality control is very strict. In case we identify any problems or contamination, we will regenerate the oligonucleotide without charge to ensure you get products of the highest quality.
Does oligonucleotide synthesis require toxic or hazardous chemicals?
Our synthesis process uses chemicals that meet international safety standards, which protect researchers from harm. Our laboratory facilities adhere to the most rigorous safety standards available.
How will my oligonucleotides be shipped?
Our oligonucleotides typically arrive at room temperature unless you specify different shipping requirements. After delivery, your oligonucleotides require storage at a temperature of -20°C to preserve them for extended periods.
VideoWhat is an Oligonucleotide?
BlogComprehensive Guide to Oligonucleotide Synthesis: Techniques, Optimization, and Purification Strategies
BlogChemical Modification Strategies for Oligonucleotides
BlogComprehensive Guide to 5'-DMTr-3'-OH Oligomers: Properties, Applications, and Synthesis
BlogA Guide to 3'-Protected Oligomers and their Protecting Groups (TBDPS/TBDMS)
As a specialist in oligonucleotide therapeutics, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.
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