For Cardiovascular Diseases

Introduction to Cardiovascular Diseases

Cardiovascular diseases are a group of diseases affecting human heart and blood vessels. Common cardiovascular diseases include coronary artery diseases heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, arrhythmia, congenital heart disease, valvular heart disease, thromboembolic disease, venous thrombosis, etc. Cardiovascular diseases are the leading cause of death worldwide except Africa. Cardiovascular diseases resulted in a total of 17.9 million deaths (32.1%) in 2015, up from 12.3 million (25.8%) in 1990.

There are many risk factors for cardiovascular diseases such as tobacco use, physical inactivity, excessive alcohol consumption, unhealthy diet, obesity, genetic predisposition, poverty and low educational status, air pollution, poor sleep, etc. Up to 90% of cardiovascular diseases may be preventable if risk factors are avoided. Prevention measures for cardiovascular disease mainly include:

• Maintaining a healthy diet.
• Decrease non-HDL cholesterol.
• Decrease psychosocial stress.
• Limit alcohol consumption to the recommended daily limits.
• Decrease body fat if overweight or obese.

Oligonucleotide Therapeutics for Cardiovascular Diseases

In the past year, a number of clinical trials on oligonucleotide therapeutics for cardiovascular diseases have been published. Some appealing gene targets for silencing include PCSK9 (Proprotein Convertase Subtilisin/Kexin type 9), ANGPTL-3 (angiopoietin-like), APOB (coding for apolipoprotein B), LPA (coding for Lipoprotein A), APOC3 (coding for apolipoprotein C3), etc. Table 1^[1] summarizes the major results from by phase 1-2 trials using oligonucleotides directed against such targets. Inclisiran can be considered the paradigm of this class of new drugs, which is a small interfering RNA (siRNA) able to silence PCSK9.

Table 1. Main clinical applications of oligonucleotide therapeutics currently in progress in cardiovascular diseases.

We are Developing Products for Cardiovascular Diseases

We currently are developing oligonucleotide therapeutics for the treatment of cardiovascular diseases. Our goal is to develop a comprehensive treatment scheme that can effectively address the complex nature of these diseases and provide better outcomes for patients. Listed below are the products we are developing for the treatment of cardiovascular diseases. If you are also interested in these, please contact us. We can provide technical support for your projects.

Our products and services are for research use only and cannot be used for any clinical purposes.

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