DNA Nanostructure-Based Delivery Systems

There is a wide variety of DNA nanostructures and many of them have been used for oligonucleotide therapeutic delivery. DNA nanostructures have typical self-assembly due to the base pairing complementarity of their constituent parts. In comparison to other methods, DNA nanostructures can be designed with precise geometries so that their physical properties such as size, flexibility and shape can be fine-tuned in order to maximize their delivery potential.

Advantages of DNA Nanostructures for Oligonucleotide Therapeutic Delivery

As an attractive and relatively new candidate for oligonucleotide therapeutic delivery, self-assembled DNA nanostructures perform multitudinous superior properties that can be summed up as the following^[1].

Common DNA Nanostructures Used for Oligonucleotide Therapeutic Delivery

DNA nanostructures have emerged as versatile and effective platforms for the delivery of therapeutic oligonucleotides, such as antisense oligonucleotides (ASO), small interfering RNA (siRNA), and immunostimulatory oligonucleotides. These nanostructures can be precisely engineered to enhance the stability, targeting, and cellular uptake of the oligonucleotides. Below are some of the common DNA nanostructures used in oligonucleotide therapeutic delivery:

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Alfa Chemistry is proficient in the drug delivery technology of oligonucleotide therapeutics and provides solutions to improve the delivery efficiency and security of oligonucleotide therapeutics. You can also contact us directly to customize DNA nanostructures to speed up your project.

Our products and services are for research use only and cannot be used for any clinical purposes.

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