LipoSwift LNP - In Vivo Gene Editing Kit

The in vivo series is developed using proprietary lipid nanoparticle (LNP) technology, systematically designed to meet diverse in vivo nucleic acid application needs, achieving high delivery efficiency, precise targeting, and excellent biocompatibility. One of the key features of this series of kits is its ease of use while maintaining a high transfection efficiency. It is designed for a simple, single-step encapsulation process that does not require any specific LNP encapsulation equipment.

The LipoSwift LNP – In Vivo Gene Editing Kit is a next-generation delivery system tailored for in vivo gene editing applications. With the rapid evolution of genome editing technologies, particularly CRISPR/Cas9 systems, there is an increasing demand for safe, efficient, and reliable in vivo delivery solutions. The kit is specifically engineered to encapsulate and deliver the Cas9 mRNA and guide RNA (gRNA) components directly into target tissues. This enables high-efficiency, site-specific genome modification within living organisms while maintaining minimal off-target effects and reduced systemic toxicity. The kit is suitable for a wide range of applications, including gene knockouts, gene insertions, and single nucleotide polymorphism (SNP) corrections, both in cultured cells and in whole animal models. By simplifying the in vivo delivery of CRISPR/Cas9 systems, the kit empowers scientists to accelerate their research in various fields, from fundamental biology to the development of novel gene therapies. Our technology is not just about making delivery possible; it's about making it effective, reliable, and accessible to a broader scientific community.

• High Delivery Efficiency: The LipoSwift LNP formulation has been optimized for rapid cellular uptake and efficient endosomal escape, enabling high intracellular delivery of Cas9 mRNA and gRNA. This results in elevated gene editing efficiency in targeted tissues without compromising cell viability.
• CRISPR/Cas9 System Optimization: Formulated specifically for co-delivery of Cas9 mRNA and gRNA, the LipoSwift LNP system maintains optimal stoichiometry between these components, maximizing editing efficiency and minimizing background activity.
• Single-Step Encapsulation Without Special Equipment: The kit enables encapsulation in one simple step using standard laboratory pipettes, drastically reducing the time and cost associated with LNP preparation.
• High Transfection Efficiency: Performance benchmarks show that LNPs prepared with this kit achieve transfection efficiencies comparable to LNPs made with professional encapsulation systems, ensuring that researchers do not compromise on data quality when opting for simplicity.
• Excellent Biocompatibility: The proprietary lipid composition of LipoSwift nanoparticles is optimized for low immunogenicity and high stability in physiological environments, ensuring minimal adverse effects and better tolerability in vivo.
• Scalability for Diverse Applications: The kit supports applications ranging from small-scale exploratory experiments to larger preclinical studies. Formulation parameters can be adjusted within provided guidelines to match the requirements of different study designs.

To demonstrate the superior performance of the LipoSwift LNP - In Vivo Gene Editing Kit, we have conducted extensive in vivo studies. The data consistently show high levels of gene editing in target tissues.

LipoSwift LNP - In Vivo Gene Editing Kit User Manual